The Lab Notes

Dr John Studley, Scientific Director at Scientific Update recently spoke to Dr Boris Gorin, Eurofins Alphora, Toronto, Canada ahead of his presentation at the 2019 ‘Organic Process Research & Development’ Conference in Toronto, Canada. Boris will talk about “Eribulin Mesylate, a Journey from Synthetic Route Discovery to Scale-Up Manufacture”. John Studley (JS): Can you tell us a bit…

Chemical Industries Association (CIA) Awards Celebration Thursday 13th June 2019 St George’s Hall, Liverpool Scientific Update is proud to sponsor the ‘Young Ambassador’ Award at the Chemical Industries Association (CIA) Awards Celebration in Liverpool, 13th June. This award will be presented to an outstanding young person demonstrating communication skills and leadership associated with the chemical…

Following a communication from a chemist at Merck / MSD I can now tell you about 2 more cocrystal APIs on the market - Lexapro (escitalopram oxalate) and Steglatro (ertugliflozin pyroglutamic acid cocrystal.  Lexapro is actually a cocrystal of the salt escitalopram oxalate with oxalic acid, similar in some ways to the Praziquantel intermediate naproxen…

The keynote speaker at our recent 'Polymorphism and Crystallisation' Conference in Boston was Dr Susan M. Reutzel-Edens from Eli Lilly, whose name will very familiar to anyone working in the solid form / crystallisation and she gave what one delegate described as “the best talk I have ever heard”. Now I can’t entirely agree with…

There are now 3 cocrystal API’s (Entresto, Suglat, and Depakote) on the market meaning that this area is no longer just an academic curiosity. Entresto is a cocrystal formed from the sodium salts of sacubitril and valsartan, but I do not know whether that is affected by the current furore over N-nitrosoamine impurities found in…

[caption id="attachment_5370" align="alignright" width="220"] Dr David Leahy[/caption] Dr John Studley, Scientific Director at Scientific Update recently spoke to Dr David Leahy, Takeda, USA ahead of his presentaion at the 2019 Catalysis in the Pharmaceutical and Fine Chemical Industry Conference in Lucerne, Switzerland. David will talk about “A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis”- following on…

Dr John Studley, Scientific Director at Scientific Update recently spoke to Professor Ben List, Max Planck Institute, Germany ahead of his Key Note lecture at the 2019 Catalysis in the Pharmaceutical and Fine Chemical Industry Conference, in Lucerne, Switzerland. Ben will talk about “how we have designed and developed a novel class of extremely reactive…

The use of fluorine and fluorine-containing functional groups in medicinal chemistry, agrochemicals and advanced materials has grown over the past fifty years.1 Not surprisingly this increase in utility tracks with notable developments and refinements in safe and accessible synthetic methodology, both on the discovery and development front and in subsequent manufacturing. A recent example that caught…

Osmium, a group 8 d-block transition metal discovered in 1803 by the English chemist Smithson Tennant, is the rarest of the stable elements. Concentrations in the Earth’s crust are around 50 parts per trillion. The metal is found in nature uncombinrd or alloyed with its neighbour, iridium, in the alloys iridosmine or osmiridium. Around 500Kg…

When approaching the synthesis of an aryl- or heteroaryl- amine most people would turn to a suitable transition metal (Pd, Cu or Ni) catalysed C-N cross-coupling reaction- most likely a Buchwald-Hartwig reaction, or, if this has limited success, Ullmann or Chan-Evans-Lam couplings.1 Photoredox approaches using aryloxy amides as a source of amidyl radicals began a trend…