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Find Out MoreRT @SciUp: Join us online for our 'Work Up and Product Isolation' short course on 23-24 February & you will lean how to design simple and p…
Join us in Boston, US in May to get up-to-date intel on #flowchemistry.Our '5th Flow Chemistry & Continuous Processing' Conference provides you with the perfect opportunity to learn from industrial and academic flow experts.Find out more and Book Now @ https://t.co/i36aLRKNTQ https://t.co/QjqN7E7XdE
RT @SciUp: Impurities - How Do You Combat Those Elusive Threats?Read our new blog post at https://t.co/ShochSm1Ub#Impurities #Pharma #…
Lithiation‐Functionalisation of Triazoles Bearing Electron‐Withdrawing N‐Substituents: Challenges and Solutions 🔓 https://t.co/2XNAMzmT26
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Forthcoming
Conferences
13 March 2023 -
15 March 2023
Organic Process Research and Development
Florida, USA
Book Now View Details08 May 2023 -
09 May 2023
Flow Chemistry and Continuous Processing Conference
Boston, USA
Book Now View Details15 June 2023 -
15 June 2023
Empowering Women in Organic Chemistry Europe
Manchester
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Training
13 February 2023 -
17 February 2023
Understanding Polymorphism and Crystallisation Issues in the Pharmaceutical Industry
Online Platform
Book Now View Details20 February 2023 -
24 February 2023
Design, Development and Scale-Up of Safe Chemical Processes and Operations
Online Platform
Book Now View Details Brochure23 February 2023 -
24 February 2023
Work Up and Product Isolation – Short Course
Online Platform
Book Now View DetailsForthcoming
Webinars
Latest from The Lab Notes
Our Collection of Articles and News
A Mild Method for Dehydration of a Base-Sensitive Primary Amide- Toward a Key Intermediate in the Synthesis of Nirmatrelvir
Nirmatrelvir, the active ingredient of the Pfizer drug Paxlovid (Figure 1), is an inhibitor of the SARS-CoV-2 main protease enzyme.1 A key transformation- the final synthetic step in the synthesis of Nirmatrelvir- is dehydration of a primary amide (Figure 2).The amide starting material is prepared by reaction of the corresponding ester with ammonia.2 Various methods
Impurities – How Do You Combat Those Elusive Threats?
Many organic impurities, such as nitrosamines, are known to be harmful to human health. Therefore, regulatory bodies and government set strict limits to protect us all. Even in small quantities, pharmaceutical impurities can have serious negative health impacts and influence the behaviour and efficacy of a drug. Organic impurities fall into a number of categories.
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