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Phase Transfer Catalysis Tips and Abstracts from PTC Organics, Inc

A patent just issued last month to Sachem, one of the most veteran manufacturers of high purity quaternary ammonium phase-transfer catalysts, that describes how to inhibit color formation of quat hydroxides in non-aqueous solvents (glycols). Sachem has been a leader in the commercial supply of quat hydroxides, especially those used in the manufacture of semiconductors.

Recent Progress in Decarboxylative Oxidative Cross Coupling

A short review article, also from the group of Igor Larrosa at Manchester, on the use of aromatic carboxylic acids as coupling partners in biaryl synthesis, appeared earlier in European Journal of Organic Chemistry (2017, 3517-3527). It is suggested in the micro-review that benzoic acid derivatives are atom-economic alternatives to traditional cross  coupling partners, and

Transition-Metal-Free Decarboxylative Bromination of Aromatic Carboxylic Acids

The brominative decarboxylation  reaction was demonstrated over a hundred and fifty years ago by Borodin (the famous composer, whose day job was as Professor of Organic Chemistry) and later developed by Hunsdiecker, whose name the reaction now bears. From an industrial viewpoint the transformation would be useful but the need to have a stoichiometric silver

Industrial Phase Transfer Catalysis

Phase-transfer catalyst or PTC is a catalyst that facilitates the migration of a reactant from one phase into another phase where reaction occurs. Phase-transfer catalysis is a special form of heterogeneous catalysis. Ionic reactants are often soluble in an aqueous phase but insoluble in an organic phase in the absence of the phase-transfer catalyst. The catalyst functions like a detergent for solubilizing

Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids

Published in Green Chemistry in 2018 C. Oliver Kappe is our tutor on our Flow Chemistry course and this abstract was published in Green Chemistry showing a collaboration with Lonza in making an API in flow. Abstract: Fluoroform (CHF3) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity

Photo-Redox Catalysis

If you had suggested 10 years ago that it would be a good idea to try and develop some of the reactions that you can now carry out using photoredox catalysis, you would probably have been labelled as deluded, if you were not locked away for your own safety.  But photoredox catalysis has come a

OPRD US 2018 Conference

We had a fantastic turn out for our #OPRDUS18 Conference in Clearwater, Florida last month. It was great to see our speakers, exhibitors and attendees and the feedback we received was excellent. Thank you for coming along! Our Technical Director Dr Will Watson opened the conference and we invited Dr Paul Murray and Dr André de

Are you using DoE to its full potential?

Where can DoE fit in process development? Are you using DoE to its full potential? A common misconception with experimental design in chemistry is that its use comes once a process had been planned and tested, just before commercialisation. In fact, DoE is arguably more useful at the start of a process for efficiently screening

Why does the management of impurities scare people?

A recent survey suggested that out of all CMC topics the one at the forefront of many people’s minds and concerns is that of impurity control.  Why might that be the case? After all there is a strong framework provided by ICH in the form of ICH Q3A / Q3B (Impurities in drug substance and