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New Award for Women in Chemistry

I am delighted to share with you the announcement of a new award and a ‘call for nominations’. The ‘1st Dr Margaret Faul Women in Chemistry Award‘ is intended to recognize and highlight outstanding contributions by young women to research in organic chemistry. The prize provided by Thieme includes an award of € 5,000. For more

Working with Britest on a new course on Chemical Engineering

Britest is a leading exponent of whole process design for the chemical, pharma and other process manufacturing industries. We are pleased to be collaborating with Britest on our course ‘Chemical Engineering: What Scientists and other Engineers Need to Know’. This course has been developed, and is presented, by chemical engineers and chemists who specialise in facilitating knowledge

John Studley to join Scientific Update as Scientific Director

Scientific Update is delighted to announce the appointment of Dr John Studley, formerly Head of Process Chemistry for Vertex Pharmaceuticals, UK. John will join the team at Scientific Update in August 2018 as Scientific Director bringing over 20 years’ experience in drug discovery, process chemistry and scale up, having previously worked for Rhone-Poulenc, Oxford Asymmetry and Vertex

Chromatographic Processes

Preparative chromatography is a versatile purification technique used in various industrial sectors including petrochemistry, sugar production, pharmaceutical and fine chemistry, to name only a few. While this technology is often considered complex, expensive and sometimes not scaleable, industrial success stories prove the opposite. In our recent webinar, Dr. Pfister from Ypso-Facto presented a reliable approach

Phase Transfer Catalysis Tips and Abstracts from PTC Organics, Inc

A patent just issued last month to Sachem, one of the most veteran manufacturers of high purity quaternary ammonium phase-transfer catalysts, that describes how to inhibit color formation of quat hydroxides in non-aqueous solvents (glycols). Sachem has been a leader in the commercial supply of quat hydroxides, especially those used in the manufacture of semiconductors.

Recent Progress in Decarboxylative Oxidative Cross Coupling

A short review article, also from the group of Igor Larrosa at Manchester, on the use of aromatic carboxylic acids as coupling partners in biaryl synthesis, appeared earlier in European Journal of Organic Chemistry (2017, 3517-3527). It is suggested in the micro-review that benzoic acid derivatives are atom-economic alternatives to traditional cross  coupling partners, and

Transition-Metal-Free Decarboxylative Bromination of Aromatic Carboxylic Acids

The brominative decarboxylation  reaction was demonstrated over a hundred and fifty years ago by Borodin (the famous composer, whose day job was as Professor of Organic Chemistry) and later developed by Hunsdiecker, whose name the reaction now bears. From an industrial viewpoint the transformation would be useful but the need to have a stoichiometric silver

Industrial Phase Transfer Catalysis

Phase-transfer catalyst or PTC is a catalyst that facilitates the migration of a reactant from one phase into another phase where reaction occurs. Phase-transfer catalysis is a special form of heterogeneous catalysis. Ionic reactants are often soluble in an aqueous phase but insoluble in an organic phase in the absence of the phase-transfer catalyst. The catalyst functions like a detergent for solubilizing

Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids

Published in Green Chemistry in 2018 C. Oliver Kappe is our tutor on our Flow Chemistry course and this abstract was published in Green Chemistry showing a collaboration with Lonza in making an API in flow. Abstract: Fluoroform (CHF3) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity

Photo-Redox Catalysis

If you had suggested 10 years ago that it would be a good idea to try and develop some of the reactions that you can now carry out using photoredox catalysis, you would probably have been labelled as deluded, if you were not locked away for your own safety.  But photoredox catalysis has come a