The Lab Notes

Here, we bring you the latest trends, in-depth analyses, and practical tips from the world of industrial chemistry and chemical engineering.

Process Chemistry Articles

Deoxyfluorination remains amongst the most frequently used method for preparing alkyl fluoro compounds.1 The reaction typically involves activation of a leaving group followed by SN2 (but occasionally SN1) reaction with fluoride ion. This is usually accompanied with significant elimination side-reactions and can frequently be low yielding. The original deoxyfluorination reagents such as DAST (diethylaminosulfur-trifluoride) and…

Conference reviews

Dr John Studley, Science Director at Scientific Update and Dr William Goundry from Astra Zeneca got together ahead of our forthcoming Organic Process R&D Conference in Lisbon, Portugal on 23-25 September. Dr William Goundry Q: Dr John Studley (JS) We are looking forward to your presentation ‘The Good, the Bad and the Ugly! Successes and…

General

One of the most significant technological advancements in synthetic organic chemistry in recent years is the use of photoredox catalysis to generate synthetically useful radical intermediates and promote novel reactivity. It has the potential to enable exploration of chemical space that remains difficult to access using traditional synthetic methodology and too improve the efficiency of…

General

When I started my PhD one of my then colleges spent months trying to make something that was sitting on a shelf in the chemical store room less than ten feet from their bench. Could there really be anything more frustrating? Well yes there could. Imagine finding a new catalytic process or synthetic transformation only…

Process Chemistry Articles

Scientific Update are delighted to sponsor 10 PhD students to attend and present their work at the '6th Winter Process Chemistry Conference' which takes place in Birmingham, UK | 9th-11th December 2019. More DetailsApplication Form

Process Chemistry Articles

Aryl boronates are among the most widely used synthetic intermediates in the pharmaceutical and agrochemical industries, both in R&D and commercial manufacture.1 Historically these key building blocks have been made using transition metal (Pd, Cu, Ni) catalysed cross coupling reactions between an appropriate aryl halide (usually bromide,  iodide or activated chlorides) and an alkoyboron species.2 Efforts to…

Process Chemistry Articles

Netarsudil- a ROCK kinase inhibitor marketed by Aerie pharmaceuticals as RhopressaTM- was recently approved by the FDA for ocular hypertension.1 An asymmetric synthesis is challenging due to the aryl group lowering the pKa of the α-hydrogen, rendering it very susceptible to racemization both during synthesis of the amino acid and subsequently amide coupling to an unreactive, poorly…

General

Dr John Studley, Scientific Director at Scientific Update recently spoke to Dr Boris Gorin, Eurofins Alphora, Toronto, Canada ahead of his presentation at the 2019 ‘Organic Process Research & Development’ Conference in Toronto, Canada. Boris will talk about “Eribulin Mesylate, a Journey from Synthetic Route Discovery to Scale-Up Manufacture”. John Studley (JS): Can you tell us a bit…

General

Chemical Industries Association (CIA) Awards Celebration Thursday 13th June 2019 St George’s Hall, Liverpool Scientific Update is proud to sponsor the ‘Young Ambassador’ Award at the Chemical Industries Association (CIA) Awards Celebration in Liverpool, 13th June. This award will be presented to an outstanding young person demonstrating communication skills and leadership associated with the chemical…

Process Chemistry Articles

Following a communication from a chemist at Merck / MSD I can now tell you about 2 more cocrystal APIs on the market - Lexapro (escitalopram oxalate) and Steglatro (ertugliflozin pyroglutamic acid cocrystal.  Lexapro is actually a cocrystal of the salt escitalopram oxalate with oxalic acid, similar in some ways to the Praziquantel intermediate naproxen…