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Scientific Update Consulting team collectively provide a wealth of experience, both through their exposure to cutting edge trends and current thinking from attendance at conferences, scanning the literature and client interactions as well as their own personal industry experience, enabling them to provide an unique and objective perspective on each process or issue for a diverse range of problems.

Scientific Update provides a wide range of consultancy services, both business and scientific, to the chemical and pharmaceutical industry, and its consultants have acted as expert witness in patent litigation.

Scientific Update Consulting provide consultancy for many of the big pharmaceutical companies and have wide experience in small pharma, virtual pharma and generics and have taken products all the way to successful launch with virtual companies.

The team has substantial breadth and depth of experience and knowledge in pharmaceuticals, fine chemicals and related fields, such as polymorphism and other solid form issues, especially in the field of organic process research and development with the Consultants sitting on the scientific advisory boards of a number of companies.

Scientific Update Consultancy also offers project management services for emerging pharmaceutical companies and advice relating to the strategic management of drug development programmes.

Meet the Team

Andrei Zlota

Expert in Quality by Design

Andy Wells

Consultant

Bryan H. Norman

Consultant

C. Oliver Kappe

Professor of Chemistry

Corinne Kay

Consultant

John Studley

Scientific Director, Scientific Update Ltd

John Surtees

Consultant – Process R&D and Industrialisation

Michael Willis

Professor of Chemistry

Paul Murray

Consultant

Philip J. Parsons

Professor of Organic Chemistry

Stuart G. Levy

SGL Chemistry Consulting

Will Watson

Technical Director, Scientific Update Ltd

Contact one of our scientific team, not only will you have to access the breadth and depth of their knowledge, but your will also benefit from exposure to the entire Scientific Update network!

For further information and to find out more about how Scientific Update consulting services, training or conferences could benefit your company, please call +44 (0)1435 873062 or e-mail the team using their links above.

CALL US

+44 (0)1435 873062

to find out how consulting services, training and conferences could benefit your company.

Andrei Zlota

Expert in Quality by Design

  • Quality by Design (QbD)
  • Statistical design of experiments (DoE)
  • QbD Chemical Process Scale-Up
  • Process Analytical Technology (PAT)
  • QbD Crystallization process scale-up
  • QbD Micronization process scale-up

Andy Wells

Consultant

  • Chemical route design and selection.
  • Biocatalysis/Industrial biotechnology (IB)– training, scale-up, regulatory issues, understanding the supply base.
  • Economic cost benefit analysis of hybrid chemical-IB routes
  • Process understanding and troubleshooting
  • Green chemistry and sustainable chemical manufacturing
  • Green chemistry tools and training
  • Solvent selection & use
  • Setting up and managing research consortia, grant funding, especially Innovate UK and EU Innovative Medicines Initiative funding.

Bryan H. Norman

Consultant

  • Drug Discovery
  • Medicinal and Synthetic Chemistry
  • Biomarkers and Pharmacokinetic / Pharmacodynamic (PK/PD) Relationships
  • Pain and Inflammation
  • Mechanisms of Drug Metabolism
  • Toxicology / Safety Risk Mitigation /  Drug Induced Liver Injury
  • Due Diligence

C. Oliver Kappe

Professor of Chemistry

  • Continuous Flow Chemistry
  • Microreaction Technology
  • Synthesis of Active Pharmaceutical Ingredients

Corinne Kay

Consultant

  • Characterisation of orphan proteases, design of universal substrate libraries.                                                                                                                                        Amour, A., Bird, M., Chaudry, L., Deadman, J., Hayes, D., Kay, C. (2004) ‘General considerations for proteolytic cascades’. Biochem. Trans., 15 (32), 15.
  • Solid phase methodologies, linkers, single bead characterization.                                                                                                                                                                Williams, G. M., Carr, R. A. E., Congreve, M. S., Kay, C., McKeown, S. J., Murray, P. J.; Scicinski, J. J.; Watson, S. P. (2000) ‘Analysis of solid-phase reactions: Product identification and quantification by use of UV-chromophore-containing dual linker analytical constructs’. Angew. Chem., Int. Ed., 39, 18, 3293.
  • Lead discovery, GPCR.

John Studley

Scientific Director, Scientific Update Ltd

John started his industrial career at Rhone-Poulenc (formerly RTZ chemicals) in Avonmouth- Bristol, working on fluorination technology, before gaining a chemistry degree and organic chemistry PhD at the University of Bath in 1995. He then did postdoctoral research at the University of Sheffield before joining the process chemistry group at Oxford Asymmetry working on route development and optimization, scale-up and custom synthesis.

In 1999 John joined Vertex Pharmaceuticals (Europe) in the discovery chemistry department, spending a number of years working in oncology and inflammation therapeutic areas. He then formed a scale-up group to support synthesis of pre-clinical candidate molecules and intermediates and in 2010 oversaw construction and commissioning of a new kilo lab facility. In 2012 John was appointed to head of process chemistry for Vertex (Europe), overseeing synthesis of compounds for preclinical toxicology assessment, designing safe, scalable synthetic routes and working with external vendors and global CRO’s to deliver key intermediates and develop new enabling technologies. He was also responsible for developing chemistry for cGMP synthesis of early phase clinical material.

John recently joined Scientific Update as Scientific Director. He is involved in running training events and advising on scientific content for the conference programme. He also supports the consultancy arm of the business and has a keen interest in scientific writing and communication.

John Surtees

Consultant – Process R&D and Industrialisation

  • Support for API development & manufacturing projects
  • Route selection and process R&D
  • Second generation process development
  • Process optimisation and troubleshooting
  • Development of external partnering strategy
  • Selection of process R&D and manufacturing partners
  • Initiation & oversight of API outsourcing activity
  • Establishing technology partnerships

Michael Willis

Professor of Chemistry

  • Coupling reactions – palladium catalysis, copper catalysis
  • Sulfur dioxide and carbon monoxide in catalysis
  • Rhodium catalysed C-C bond formation
  • Hydroacylation

Paul Murray

Consultant

  • Consulting and training in Design of Experiments (DoE)
  • Principal component analysis (PCA)
  • Process development
  • Homogeneous and heterogeneous catalysis
  • Metal removal and metal recovery

Philip J. Parsons

Professor of Organic Chemistry

  • Legal services including patent litigation with synthetic backup
  • Identification and synthesis of pharmaceutical and agrochemical impurities
  • Alkaloid chemistry and synthesis
  • Photochemistry
  • Innovative heterocyclic chemistry
  • Transition metal mediated cascade sequences and cyclisations
  • Route design for multi step synthesis

Stuart G. Levy

SGL Chemistry Consulting

  • Chemical development
  • Vendor selection, engagement and management
  • Problem solving
  • Assistance with Strategy and Management of Drug Development Programs
  • Technical and Regulatory Documentation
  • Regulatory/QA

Will Watson

Technical Director, Scientific Update Ltd

  • Process development
  • Scale up
  • Crystallisation
  • Green chemistry
  • Thermal hazards
  • Synthetic route selection