Join the Scientific Update Newsletter

Newsletter Issue 48 June/July 2013

Scientific Updates' What's New in Process ChemistryScientific Update
What's New in Process Chemistry.

11 Key Solvent and Work Up Tips

Dr John Knight Dr Will Watson

Eleven tips Solvent and Work Up Tips from Dr John Knight and Dr Will Watson of Scientific Update.

  1. Add 10% heptane to cyclohexane to avoid freezing at 4°C
  2. Addition of 10% alcohol to hexane, reduces electrostatic hazards See for example T.J. Connolly et al (Raylo), Org. Proc. Res. Dev.,2000,4, 526

 

Drying N-Methyl morpholine N-oxide 50% aqueous solution


Dr Will Watson


N-Methylmorpholine N-oxide (NMO) is commercially available in bulk as a 50% aqueous solution.  Anhydrous material is available but only in small quantities.

Azeotropic drying of a biphasic mixture with toluene or with alcohols stopped at the monohydrate stage and in the case of toluene resulted in crystallisation of the monohydrate as a solid mass.  Full water removal is possible with ethylene glycol or propylene glycol but the solution darkens on prolonged heating.  This can be circumvented by using a wiped film evapor

Industrial Applications of the Diels Alder Reaction


Dr Trevor Laird

A comprehensive review of industrial applications of the Diels-Alder reaction has recently appeared in Angewandte Chemie International Edition (2013,52, 3822-3863), compiled by researchers at Actelion, Switzerland.

Introduction of Fluorine into Unactivated Molecules


Dr Trevor Laird

The importance of fluorine-containing compounds in industrial applications is on the increase, with pharmaceuticals, agrochemicals and new materials being the major users.  Thus there have been corresponding advances in ways to introduce fluorine into unusual positions, sometimes using free radical chemistry.

Book Review - Chemistry for Sustainable Technologies – A Foundation


Dr Trevor Laird

The scope of the book is to explain the concept of sustainability, to highlight the role of science and technology in moving towards sustainable development, and to use examples of new approaches to chemistry to meet these needs. Metrics is given a central role in the discussions.

Book Review - March’s Advanced Organic Chemistry – 7th Edition


Dr Trevor Laird

Good news! The 7th edition of “March’s” is now available.

The bad news! It’s even heavier than the 6th edition. Of course this means that the new edition has been rewritten and updated to include advances in organic chemistry in the period 2005-2010, with more than 5500 new references added.

Join our growing community Join our linked in community @ Scientific Update

We invite you to share and comment on to blogs from leading consultants and experts, John Knight and Will Watson and to join us on our LinkIn network.

Bookmark and Share

Don't Forget
if you have a useful, novel or new methodology, please send it to us, to share this with our extensive international network of organic process chemists (sent to over 15,000 readers!)

right first time in-scale-up

Right First Time in Fine-Chemical Process Scale-Up

A New Book by Bert Hulshof
495 Pages (A4) £99.50 plus P&P

"...essential reading for all chemists and engineers... "

credit cards

 

Dates for your diary...
Click to view our 2013
Conference and Course Dates

 

CONFERENCES

COURSES

Organic Synthesis

09 - 11 May 2017


Stretch your training budget - register 2 or more delegates and SAVE up to 15%!

Seeing is believing.
Explore the benefits of networking at one of our prestigious events with video from one of our conferences.

Not a Subscriber?
If you or a colleague would like to receive future copies of 'What's New in Process Chemistry', click here

Bookmark and Share

 
 
www.scientificupdate.co.uk info@scientificupdate.co.uk
© 2013 Scientific Update LLP. All rights reserved.

This is an advertising message from Scientific Update LLP, Maycroft Place, Stone Cross, Mayfield, East Sussex, TN20 6EW
If you'd prefer not to receive e–mail like this from Scientific Update in the future, please click here to unsubscribe or send an e–mail to . Alternatively, you may mail your unsubscribe request to:


Scientific Update LLP, Maycroft Place, Stone Cross, Mayfield, East Sussex, TN20 6EW