Single atom deletion and skeletal editing of complex organic molecules is an interesting and potentially very impactful area of research. Over 100 papers mentioning the term ‘skeletal editing’ have been published in the past 2 years. The ability to selectively add or remove a single heteroatom from a molecules core architecture is distinctly different from

A well-written experimental protocol is one of the hallmarks of good process chemistry that we teach at Scientific Update in our Chemical Development course, so in this blog I thought I’d highlight an excellent example recently published in an open-access article by Nicholas Isley and Fabrice Gallou from Novartis (Helv. Chim. Acta 2023, 106, e202300143,