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It Ain’t Easy Being Green

One of my recent bugaboos has been the increase in the number of papers claiming a “green” synthesis, reagent, process or solvent. It seems that I am not alone in my concerns of the misuse of words such as “green” and “sustainable” based on a recent paper called ‘What does it mean that “something is

Hey Phenol- Everyone has their Cross to Bear

Tert-butyl phenols are important commodity chemicals, with annual production exceeding 120,000 t per annum. They have multiple industrial applications including agrochemicals, antioxidants- in particular 2,6-di-tert-butyl-4- methylphenol (BHT, Figure 1), foods, flavours and fragrances and pharmaceuticals.1 BHT in particular, used as an antioxidant in polymers and oils and prepared by reaction of p-cresol with isobutylene in

Pd Atom Catalysis – What’s Going On?

A number of years ago, during a scale-up campaign, I worked to try and convert a relatively simple, high-yielding Suzuki coupling from a relatively standard set of homogeneous coupling conditions to heterogeneous conditions using a palladium on carbon (Pd/C) catalyst. The reason for making the change was that although the homogeneous conditions worked very well,

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