Deuterium in Organic Chemistry and Drug Discovery

14 November 2018

Event overview

This FREE to attend webinar was presented by Dr John Studley, Scientific Update.

John will cover the following topics:

  • General introduction-, discovery, natural abundance etc
  • Why is deuterium of interest to chemists?
    • Physical properties and comparison to proteo- compounds
    • Applications
    • Key articles to read for further information
  • D2 and D2O
    • Methods of production in the lab and commercial production processes
    • Girdler sulphide process
  • Suppliers of deuterated raw materials intermediates and prices
    • How are deuterated solvents made?
    • Shipping deuterated raw materials
  • Analysis of deuterated organic compounds
    • Mass spec and NMR
    • Isotopic purity
  • Deuterium kinetic isotope effect (examples)
    • Deuterium tracer for reaction mechanism elucidation
  • Deuterium in drug discovery and development
    • Stable isotope labels
    • In vivo effects of deuterium containing compounds (PK/PD effects)
    • Elucidation of metabolic pathways
    • Deuterium in medicinal chemistry- “leaving the label in the drug”
    • Deutetrabenazine- the first FDA approved (2017) deuterated drug (mechanism, benefit)
    • Deuterated Linoleic acid and use of deuterium to reinforce oxidation-vulnerable C-H bonds within nutrients
    • Examples of other deuterated compounds in development
      • Big pharma pipelines
      • Concert pharmaceuticals model
      • Several case studies and examples
    • Regulatory issues
      • FDA 505 (b)(2) and 21 U.S.C. 355(b)(2)
      • Expedited rote to approval
    • Patent issues and obviousness analysis
  • Methods for synthesising deuterium labelled compounds
    • Deuterated reagents (e.g. LiAlD4, LiBD4, NR3.BD3)
    • MacMillan’s photoredox approach to deuterated API’s
    • C-H functionalization approaches
    • Metal-mediated approaches
      • Alpha-deuteration of amino acids and amines at scale
    • Incorporation of deuterium into heterocycles
  • Introduction to the use of Tritium
  • Short introduction to other isotopes- C13, C14, N15 and radio-isotopes

 

 

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Deuterium in Organic Chemistry and Drug Discovery

14 November 2018

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