Safety & Selectivity in the Scale-Up of Chemical Reactions
Event overview
The safety of chemical processes is critical for the whole chemical industry. It is vital that process development chemists and engineers are able to identify aspects of the chemistry that may be hazardous or pose a risk to the safety of the process or equipment.
In order to do this they need to know when to proactively engage colleagues or contractors to carry out process safety testing and hazard analysis, which in turn requires a knowledge of the equipment and test methods available.
As chemical reactions are scaled up and operations become more economic the ability to remove heat from exothermic events becomes reduced and at the same time the outcome of any incident becomes much more severe.
This is an almost unique course on the safety of chemical reactions and processes that is designed by chemists for chemists (and engineers) with the ultimate aim of helping the chemical industry reduce the number of chemical or process related incidents.
Course Outline
The aim of the course is to give lab chemists an understanding of the issues that need to be considered during the early stages of scale up to large laboratory scale equipment (10-20 litre vessels) / kilo lab. The course will concentrate on chemical safety and selectivity issues and include information on what safety testing equipment is available and the uses and limitations of this equipment. Attendees will learn how to identify potential problems whether they be thermal hazards or selectivity issues. Methods used by other companies for handling hazardous reagents and reactions will be described as well as alternative chemistry to circumvent these reactions and/or reagents.
Topics include:
- Introduction
- Improving Safety and Selectivity in Chemical Reactions
- Thermal Hazard Testing and Runaway Reactions
- Oxidation
- Reduction
- Solvent Selection and Solvent Effects
- Azide and Diazo Chemistry
- Scaling Up Chemical Reactions
- Work Up
- C-C Bond Forming Reactions
- Curtius and Related Rearrangements
- Recommendations
Benefits of Attending
- Attendees will learn how to identify potentially unsafe chemical processes, particularly those that pose more a danger on scale
- They will learn about what testing procedures are available to help them identify unsafe operating conditions to enable to talk knowledgably to in-house safety professionals or contract organizations
- Sources of safety information in the literature and via the internet will be provided
- The course provides lists of reagents and functional groups that should trigger safety testing studies
- Methods used in other companies for handling hazardous reagents and reactions will be provided
- Alternatives reagents or substitutes for hazardous materials will also be discussed
- Recommendations will be provided for making the first sample of a product where there may be safety or stability concern
Who Should Attend
- Process chemists with 3+ years industrial experience
- Chemists who have attended the Chemical Development course and are looking more advanced training
- Laboratory chemists involved in the scale-up to large scale equipment/kilo lab
What's Included
The course fee includes:
- comprehensive course manual
- coffee/tea refreshments breaks throughout each day
- buffet lunch each day
- course dinner on the first evening
- course certificate
Other Information
General Information
Each course includes:
- Refreshments & lunch daily
- Dinner on the first evening*
- The comprehensive Course Manual
- Course Certificate
Please refer to the course brochure for detailed timings.
*Not every course includes dinner please refer to the course brochures for detailed information on what’s included.
Course Certificate
At the end of each course participants receive a Certificate of Attendance – signed by your tutor.
Accommodation
Depending on venues we either reserve a limited number of bedrooms at a special rate for you or we will provide a list of recommended hotels close by to the course venue. More information on rates and booking forms will be provided upon booking. All rooms will need to booked directly with the hotel.
Discounts
1st delegate = full price
2nd delegate = 5% off
3rd delegate = 10% off
4 or more delegates = 15% off
For more information on discounts do give us a call on +44 (0) 1892 956 222
Brochure
View brochure
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