Olefin Metathesis for XXI Century Chemical Industry

Ruthenium-catalyzed olefin metathesis represent an attractive and powerful transformation for the formation of new carbon­-carbon double bonds. This transformation  is now quite familiar to most chemists as it offers alternative retrosynthetic strategies and is characterised by high efficiency and atom economy. During the lecture the key facts about this reaction will be presented, followed by a number of examples of application of this methodology in synthesis of natural compounds and APIs, as well as polymers and fine chemicals. For practical interest, hints on how to select the most optimal catalyst and conditions for a given substrate, as well as comments on compatibility of modern metathesis catalysts with solvents (also green solvents) and enabling techniques (including examples of metathesis in continuous flow), selectivity issues, and strategies for removal of spent catalysts will be discussed.

This webinar was presented by Professor Karol Grela, University of Warsaw in collaboration with Apeiron who kindly sponsored the presentation.

About our speaker:

Karol Grela received his PhD degree from the Institute of Organic Chemistry, Polish Academy of Sciences, in 1998. As Alexader von Humboldt Scholar, he spent one year in the Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany, just in time to be present at the blooming of metathesis methodology in the laboratories of Professor Alois Fürstner. In 2008 he was promoted to Full Professor. Since 2008, he is a Director of newly formed group at the Biological and Chemical Research Centre of the Faculty of Chemistry, University of Warsaw. His synthetic research focuses on improving synthetic efficiency of organic reactions, organometallic chemistry and catalysis. His work with metals involves the development of new catalysts and conditions for olefin metathesis. He cooperated with a number of companies, inc. Boehringer-Ingelheim Inc., Nalco Inc., Evonik AG, Umicore AG, Polpharma SA, Apeiron Synthesis SA.

About our Sponsor:

Apeiron Synthesis is a chemical company founded in 2009. The company was established to bring Nobel prize winning olefin methatesis technology to the chemical industry and demonstrate its potential as a powerful yet cost-efficient and sustainable alternative to the well-established catalytic transformations.

Apeiron thrives on helping its partners elevate their chemical processes by developing robust solutions and providing end-to-end olefin metathesis services. Apeiron’s olefin metathesis technology platform consists of best-in-class proprietary ruthenium catalysts, metal scavenging agents and services dedicated to development of catalysts tailored to individual needs , catalyst screening, metathesis derived product  development and optimization of even the most challenging metathesis processes. This powerful chemical synthesis set provides robust and scalable solutions for production of new and existing chemical products in the pharmaceutical, agrochemical, flavor & fragrance, petrochemical and polymer sectors.