Application of Solid Form and Crystallisation Science in Purification Strategies of New Chemical Modalities (NCMs) including Peptides and PROTACs

New chemical modalities (NCMs) including Protein Degraders (PROTACs, Molecular Glues), Peptides (Cyclic, Macrocyclic), Oligonucleotides and RNA therapeutics to name just a few, are emerging as novel promising pharmacological entities for the pharma industry. These diverse structural types have the potential benefit to address a wide range of therapeutic areas.

However, owing to their often-complex structure, larger molecular weight coupled with increased flexibility, the isolation and purification of these NCMs can be more challenging over more typical “small molecules”.

In this talk we outlined methodologies for isolation and purification (via crystallization) for such NCMs. This included a variety of techniques, such as solubility profiling, solvent, salt and cocrystal screening, and crystallization development. An example Peptide screening / crystallization workflow is shown below.

This presentation will be of interest to scientists in small to medium biotechs and large pharma, specifically:

• R&D scientists
• Crystallization scientists
• Analytical scientist
• Head of discovery
• Head of Process Chemistry
• Head of Chemical Development
• Head of Crystallization
• Peptide Science Group
• Consultants

This webinar was presented by Dr Richard Edwards and is sponsored by Veranova