Understanding Process Plant Cleaning for More Efficient Changeovers

On line Training Course

Date: 17 April - 19 April 2023

Location: Online Platform

Tutors: Mr Robert Peeling

The course objective is to enable participants to understand the fundamental science and engineering principles underlying process plant cleaning performance and will be covered over 3 x 3-hour sessions, combining extensive input from the course tutor, Britest Senior Innovation Specialist Rob Peeling, with ample opportunities for interactive discussion and exploration of common issues and shared experiences with fellow online trainees.

Dates and timings are below:

Monday 17 April | 2.00pm – 5.00pm BST
Tuesday 18 April | 2.00pm – 5.00pm BST
Wednesday 19 April | 2.00pm – 5.00pm BST

Effective cleaning of processing equipment is a critical patient/customer safety requirement across the process industries – notably in pharmaceutical manufacturer (in the production of Active Pharmaceutical Ingredients (API) and Drug Products), in agrichemicals and in food processing.  This is equally true for batch or continuous processing and is particularly important in multipurpose plants producing different products on a campaign basis.

The challenges of measuring the residual levels of potential contaminants in equipment and validating cleaning procedures to support regulatory submissions tend to receive considerable attention in the field.  Thinking about how to establish a thorough understanding of cleaning as a process is less common. Considering the underlying science and chemical engineering principles leads to an appreciation of why cleaning procedures sometimes fail and provides insights into how to improve cleaning performance.  This will in turn drive a better assessment of risks during cleaning and so support regulatory validation.

Ran in conjunction with

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Course outline

  • Introduction to plant cleaning
    • The washing up challenge
    • Fundamentals of plant changeover/cleaning
    • Sinner’s Circle
  • Residues
    • Types and defining residues
    • Understanding properties of residues
  • Cleaning specification
    • What is the purpose of cleaning?
    • Setting acceptance limits
    • Detection & measurement of residues
  • Engineering
    • Define the equipment
    • Characterisation of equipment cleaning challenges
    • Fundamental Engineering Principles
      • Time
      • Temperature
      • Forced and natural convection
      • Estimating heating and cooling times
      • Boiling and condensation
      • Cleaning chemistry
      • Dissolution & solubility
      • Mass transfer
      • Surface interactions
      • Solubilisation
      • Degradation
      • Driving forces
      • Enzymatic kinetics
      • Mechanical cleaning
      • Planning process plant cleaning

Course Objectives

COURSE OBJECTIVES

The course objective is to enable participants to understand the fundamental science and engineering principles underlying process plant cleaning performance.

This will enable you to

  • critically assess plant cleaning risks
  • better identify root causes of cleaning failure, and 
  • design new cleaning procedures to achieve right first-time results.

While recognising the importance of setting the right specifications for determining cleanliness, process validation and robust analytical methods to demonstrate attainment of the required standard, the course will concentrate on what is happening during cleaning operations.

Who should attend

Process development chemists and engineers, and plant operations personnel at companies, CMOs and CDMOs engaged in the manufacture of Active Pharmaceutical Ingredients, drug product, food and beverages, or agrochemical products.

What's Included

The course fee includes:

  • Link to watch all three live sessions
  • Electronic version of the course manual*
  • Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.

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Understanding Process Plant Cleaning for More Efficient Changeovers

This course is available as a face-to-face event upon request. Please provide your details and we will get back to you with further information.

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Understanding Process Plant Cleaning for More Efficient Changeovers

This course is available as an In-House event upon request. Please provide your details and we will get back to you with further information.

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