Organofluorine Chemistry: Synthesis, Applications, Sources and Sustainability

12 March 2020 - 13 March 2020
Sheraton Sand Key | Clearwater, FL, USA

Event overview

Course tutors: Dr John Studley

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The health and safety of both our colleagues and customers is always our top priority and we will continue to get the latest information concerning the outbreak from official sources, as well as updates and guidance from government authorities and the World Health Organisation.

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New Course for 2020

Organofluorine compounds are frequently encountered in the pharmaceutical, agrochemical and fine chemical industries. Often the selective introduction of a fluorine atom or functional group into a molecule can be challenging, particularly at scale, with chemists often designing synthetic routes in which fluorine is introduced through strategic sourcing of raw materials rather than synthetically.

This two-day course aims to provide an overview of fluorination technology and synthetic methods- both traditional and state of the art- highlighting industrial application. Detailed case studies are used to provide context and workshops enable delegates to familiarize themselves with the chemistry described.

Course Outline



  • Unique properties of fluorine
  • Historical context
  • Sources of fluorine
  • Handling and toxicity


Methods of introducing fluorine

  • Aromatic and heteroaromatic fluorination
  • Nucleophilic and electrophilic fluorinating reagents
  • Aliphatic fluorination
  • Heterocyclic fluorination
  • Radical methods, photoredox and electrochemistry
  • Large scale application of fluorination methods


Fluorinated functional groups

  • Trifluoromethylation, difluoromethylation, monofluoromethylation
  • Fluoroalkenes
  • SF3, SF5
  • -OCF3, OCHF2, OCH2F
  • Perfluoroalkyl


Miscellaneous fluorination methods

  • Fluorination of enolates and organometallics
  • Biocatalytic methods
  • Hydrodefluorination
  • Asymmetric fluorination
  • Late stage fluorination


Fluorine in medicinal chemistry and agrochemicals

  • Role of fluorine in drugs and agrochemicals and natural products
  • Fluorinated drugs
  • Fluorinated amino acids and proteins
  • 18F and PET


Fluorinated building blocks, synthons and materials

  • Liquid crystals and optoelectronics
  • Fluorine containing organocatalysts
  • Fluorinated solvents

Benefits of Attending

  • An extensive review of synthetic organofluorine chemistry and its application in the synthesis of pharmaceuticals, agrochemicals and fine chemicals.
  • Learn how and when to incorporate fluorine in a synthetic route.
  • Information on fluorine containing building blocks and commercial synthons.
  • An understanding of the processes involved in the development and scale-up of fluorination chemistry.
  • An appreciation of the role of fluorine in medicinal chemistry

Who Should Attend


Discovery/Synthetic organic chemists

Process development chemists

Anyone wishing to learn more about organofluorine chemistry

What's Included


The course fee includes:

  • comprehensive course manual
  • coffee/tea refreshments breaks throughout each day
  • buffet lunch each day
  • course dinner on the first evening
  • course certificate

Other Information

General Information


Each course includes:

  • Refreshments & lunch daily
  • Dinner on the first evening*
  • The comprehensive Course Manual
  • Course Certificate

Please refer to the course brochure for detailed timings.
*Not every course includes dinner please refer to the course brochures for detailed information on what’s included.

Course Certificate


At the end of each course participants receive a Certificate of Attendance – signed by your tutor.



Depending on venues we either reserve a limited number of bedrooms at a special rate for you or we will provide a list of recommended hotels close by to the course venue. More information on rates and booking forms will be provided upon booking. All rooms will need to booked directly with the hotel.



1st delegate = full price
2nd delegate = 5% off
3rd delegate = 10% off
4 or more delegates = 15% off
For more information on discounts do give us a call on 44 1435 873 062


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Organofluorine Chemistry: Synthesis, Applications, Sources and Sustainability

12 March 2020 - 13 March 2020
Sheraton Sand Key | Clearwater, FL, USA