Applied Mixing Technology for Process Development: Scaling Down to Scale Up

Date: 17 May - 20 May 2021

Location: Online Event

Tutors: Aaron Sarafinas

This is a NEW online short course and will be held Live via a Virtual Webinar Platform over four sessions – listed below.

Monday, May 17th | 2.00pm – 5.00pm BST
Tuesday, May 18th | 2.00pm – 5.00pm BST
Wednesday, May 19th | 2.00pm – 5.00pm BST
Thursday, May 20th | 2.00pm – 5.00pm BST

Course Introduction

Use of the proper mixing technology is often essential for successful process results.  This online course considers how we can choose appropriate mixing conditions for laboratory, pilot, and commercial scale units to ensure technical success.  The course begins by rooting us in some essential basics of mixing technology.  With those fundamentals, we then progress through different mixing applications in increasing levels of complexity:  single-phase (blending and heat transfer), multiple phase (solid-liquid, immiscible liquid, gas-liquid, and 3-phase), and mixing in competitive rate processes (reactions and crystallizations).  Throughout, we look at scale-up and scale-down by using examples from industrial processes which have a variety of mixing requirements.  We will discuss how to design and execute practical experiments at the small scale which can identify mixing sensitivities in a process that could be an issue on scale-up.  Though primarily focusing on operations in stirred tanks, we will also discuss mixing applications in flow systems like static mixers.



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Course Outline

  • Why learn about mixing and what is “mixing” anyway?
  • An introduction to some example industrial processes with multiple mixing requirements
  • Foundations of mixing technology:  power, flow, and “shear” (with some discussion of rheology)
  • An introduction to mixing applications, revisiting the example processes
  • Single-phase mixing applications and how they scale
    • Miscible liquid blending (macromixing)
    • Heat transfer
  • Multiple-phase mixing applications and how they scale
    • Solid-liquid mixing
    • Liquid-liquid dispersion
    • Gas-liquid dispersion
    • Three-phase mixing
  • Competitive rate processes (micromixing and mesomixing)
    • Mixing-sensitive reactions
    • Crystallizations and precipitations
  • An efficient experimental method for screening mixing sensitivities:  the Bourne Protocol
  • Balancing different mixing requirements during scale-up and scale-down:  scaling competitive rate processes and optimization

Who Should Attend

Scientists and engineers in the chemical and pharmaceutical industries who are involved in process development, scale-up/scale-down, troubleshooting, and process optimization.

Take-home Messages

  • Mixing moderates some rate processes that can be critical for successful process results.
  • Power, flow, and “shear” are the foundation upon which we can evaluate mixing applications.
  • Predicable mixing performance can be estimated for single phase and multiple phase systems, along with the boundaries of “not enough mixing” and “too much mixing”.
  • You cannot keep all mixing parameters the same when you scale up.

What's included

The course fee includes:

  • Link to watch all two live sessions
  • Electronic version of the course manual*
  • Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.