It was good. Never visited a Scientific Update conference, but will get it on my priority list. Very good – like the set-up, flow and topics. Very interested in process development.
It was good. Never visited a Scientific Update conference, but will get it on my priority list. Very good – like the set-up, flow and topics. Very interested in process development.
It was good. Never visited a Scientific Update conference, but will get it on my priority list. Very good – like the set-up, flow and topics. Very interested in process development.
The scheme below shows the synthesis of a late-stage intermediate towards AZD9833, a compound identified by AstraZeneca as a selective estrogen receptor degrader (SERD) and antagonist that is currently in phase 2b clinical trials for the treatment of ER+ breast cancer. Can you identify reagents or intermediates A, B and C? Answers and a reference will be posted in late July, along with another problem. Enjoy!
Written by Jonathan Moseley, April 17th 2024 No relation to the Madonna song, but rather the title of a book by Ed Conway, an economist and journalist, regarding the Material World in which we live. And if like me, you have a general interest in chemistry, as well as some interest in economics and history…
In this post I’m highlighting a couple of papers that are essentially two sides of the same coin. As a process chemist, I’ll be the first to admit that the chemistry I’m about to describe is not going to end up in your manufacturing route any time soon, but as a former card-carrying medicinal chemist…
In George Orwell’s classic 1945 novella ‘Animal Farm’ the revolutionary livestock develop the slogan “Four legs good, two legs bad” to summarize their views on the farmer and other humans. As the novella progresses, we see that things cannot be simplified so readily, and so I was encouraged by the recent excellent article by Brianna…
