For the past decade I have been intrigued by the emergence of micelle technology and its ability to enable many organic reactions in water, but perplexed about why the reactions work as effectively as they do, and have been waiting for more universal reaction conditions. Two recent papers address these issues. The title of the
Written By: Dr Ben Littler
Almost Two Centuries Later, Functional Group Tolerant Conditions Identified for the Electrochemical Kolbe Coupling!
Two principles that we at Scientific Update teach in the foundational “Chemical Development” course are that new experimental methods can open new opportunities for old reactions, and that as scientists we should be looking to understand the mechanisms of empirical observations. Both of these principles are exemplified in by a recent pre-print publication by the
“How many steps are there in a synthetic route?” is one of the foundational questions for any chemist, but as with many apparently simple questions, the answer isn’t always that simple. In many cases chemists are incentivized to give an artificially low step count because it makes their new route look better and therefore more
Finding generally applicable, more sustainable, scalable methods to construct C-C bonds via cross-coupling is likely to be one of the major challenges that process chemists will face over the next decade. At the moment chemists overwhelmingly rely on pre-formed nucleophilic organometallics (such as Grignard, organozinc and organoboron reagents) in C-C couplings with an electrophile (such
Acquisition and processing of analytical HPLC data is often the main bottleneck when performing automated data-rich or high-throughput experimentation. Even though it was over 20 years ago, I well remember spending most of each day running, processing and compiling HPLC data when using an automated reaction platform to run 4 data-rich time course experiments in