The Cyclopropyl Group in Medicinal Chemistry
Date: 26 August 2020
Time: 15:00 (BST), 16.00 (CEST), 10.00 (EDT), 7.00 (PDT)
Tutors: Dr John Studley
The cyclopropane ring is now part of the established molecular architecture used in drug discovery and development, with a proven track record in marketed small molecule drugs. In total 18 NCE’s containing a cyclopropyl group were approved by the FDA over the past decade. There are several reasons this small ring system is attractive to drug hunters, including coplanarity of the three carbon atoms, shorter C-C bonds with enhanced p-character, and shorter C-H bonds that tend to be stronger than those in standard aliphatic chains. The cyclopropyl ring is often used as a isosteric replacement for an alkene or as a rigid alkyl linker and is also used strategically to increase potency, increase metabolic stability and reduce off-target effects.
This webinar will look in detail at the role of the cyclopropyl ring in drug discovery and development, including a review of the synthetic approaches used to instal the cyclopropyl ring and/or key building blocks used in their assembly. Case-studies will be used to draw out the key points, with examples from contemporary clinical molecules.
This webinar will be presented by Dr John Studley, Scientific Update.
It will take place at the following time:
15.00 BST (UK, Lisbon)
16.00 CEST (Paris, Madrid, Frankfurt etc)
10.00 EDT (New York, Boston)
7.00 PDT (San Francisco, LA)
Please register for FREE using the Book Now button, if you are unable to attend on the day, do not worry, all registrants will be sent links to the recorded session and slides presented afterwards. Registrants who attend the ‘live’ session will receive an e-Certificate of Attendance.