Reaching the Pinnacle: S-Metolachlor and the Largest Industrial-Scale Enantioselective Chemical Process Ever Developed

Date: 13 November 2023

Time: 15:00 (GMT), 16.00 (CET), 10.00 (ET), 7.00 (PT)

Tutors: Dr John Studley

(S)-metolachlor, the active ingredient of the Dual Magnum herbicide, is prepared industrially via an Iridium-Xyliphos -catalysed enantioselective hydrogenation reaction. This process, first run at production scale in 1996, is the world’s largest application of a single catalytic asymmetric reaction to date. In excess of 10,000 tons per year of enantioenriched amine intermediate are produced via reduction of an imine precursor (N-(2-ethyl- 6-methylphenyl)-1-methoxypropan-2-imine -MEA imine).

The catalyst is tuned to perfection- with turnover frequencies (TOFs) exceeding 1.8×106 h-1 and turnover numbers (TONs) exceeding 2×106.Not surprisingly very detailed optimisation and extensive process understanding were important aspects in the development cycle.

This webinar looks at the journey from early reaction screening and development to an established manufacture process, highlighting general issues involved in developing large scale catalytic processes. Welcome to the greatest show on Earth!

This webinar will be presented by Dr John Studley, Scientific Update at the following time:

15.00   GMT (UK, Lisbon)
16.00   CET (Paris, Madrid, Frankfurt etc)
10.00   ET (New York, Boston)
7.00     PT (San Francisco, LA)

If you are unable to attend on the day, do not worry, all registrants will be sent links to the recorded session and slides presented afterwards. Registrants who attend the ‘live’ session will receive an e-Certificate of Attendance.


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