Ion-Exchange Chromatography: Understanding & Modeling for Efficient Process Design

Ion-exchange chromatography is based on the differences in terms of electrostatic interactions of molecules regarding an adsorbent. Nowadays, industrial processes based on ion-exchange chromatography can be found in many different sectors from the food industry for sugars softening, to the biopharmaceutical industry for protein purification, to name only a few. While this technology is often considered too complex, industrial success stories proves the opposite.

In this webinar, Dr Osuna, spoke about ion-exchange chromatography from a modeling point of view and showed how and why “ion-exchange” is conceptually different from its cousin “adsorption”. Acido-basic equilibria and complexation reactions taking place in solution strongly impact the exchange mechanism with the charged surfaces thus leading to complex and intricated interactions. Based on the rigorous description of the physical phenomena at stake, predictive models can be derived to explain and quantify experimental observations that would otherwise look mysterious. Mechanistic models provide essential understanding and representation to design robust and efficient processes and pave the way towards a successful implementation of ion-exchange chromatography at all scales.

To request a copy of the slides presented – please e-mail Hector: [email protected] 

Please also see this related 2-day course on ion-exchange chromatography “DESIGNING RELIABLE ION-EXCHANGE CHROMATOGRAPHIC PROCESSES WITH A PROVEN PREDICTIVE APPROACH”

About Ypso-Facto:

Ypso-Facto is a service company offering scientific and technical consulting, process simulation software and contract research services for chemical and biochemical processes. It was founded in 2014 by Roger-Marc Nicoud with the vision to combine strong industrial experience and scientific expertise with the complementary know-how of (bio)chemists and process engineers to develop efficient, robust and innovative processes. Ypso-Facto benefits from a strong expertise in the field of industrial preparative chromatography through its staff. In particular R.-M. Nicoud has founded and headed Novasep, an industrial leader in the field, for almost two decades and he has written a reference book on this process.¹

1.  Chromatographic Processes – Modeling, Simulation, and Design, Roger-Marc Nicoud, 672 pages, Cambridge University Press, Cambridge Series in Chemical Engineering, New-York (2015), ISBN: 9781107082366.