From Route Scouting to Robust Routes: Using SYNTHIA® Software to De-Risk Process Development

Process chemistry is a balancing act: step count vs. yield, supply chain vs. safety, cost vs. sustainability. In this webinar, we’ll show how SYNTHIA® Retrosynthesis Software helps industrial process chemists rapidly explore alternative disconnections, pressure-test route options, and make decisions with clearer trade-offs—before committing weeks to lab work. We’ll highlight practical ways to use customizable search criteria (e.g., exclude/seek specific reaction types) and route ranking/sorting to identify pathways that are easier to scale, easier to source, and better aligned with process constraints.

Overview
Process chemistry rarely fails because the chemistry is impossible. It fails because the route is fragile—too long, too costly, too hard to supply, too risky to run, or too dependent on “perfect” conditions. This webinar is built for industrial process chemists who want stronger options earlier, when changes are cheap and momentum is high.

We’ll walk through how SYNTHIA® Retrosynthesis Software can help you broaden route scouting in minutes—generating up to 50 pathways from commercially available starting materials—and then quickly narrow to the routes that are more likely to hold up under process realities: sourcing, scale constraints, safety considerations, and operational simplicity.

You’ll see practical, process-relevant workflows for steering the search using Exclude & Seek (e.g., to avoid certain reagents, reaction types or substructures), limiting starting materials based on price and quantity available, and for sorting/filtering results by the considerations process teams care about—like step count, atom economy, and scalability of reactions.

We’ll also highlight how SYNTHIA® provides important details—like starting material price and availability, chemical hazard information, relevant literature references, and predicted impurities—so you can evaluate and prioritize options with more confidence, before you commit the lab to weeks of experimentation.

Key learnings

• How to generate and compare up to 50 ranked pathways to expand route scouting beyond “the usual suspects”
• How to tailor searches to find process-friendly routes that avoid undesired reagents/reaction classes and steer toward preferred chemistry, for instance enzymatic reactions
• How to use SYNTHIA® output (e.g., starting material availability and price, predicted impurities, and reference literature) to accelerate early route-scouting workflows
• How to customize and share route ideas to facilitate brainstorming and prioritize pathways for lab evaluation

This webinar will be presented by Dr Emma Gardener, MilliporeSigma, a business of Merck KGaA, Darmstadt, Germany, who are kindly sponsoring the event. It will take place at the following time:

3.00 pm  (UK, London)
4.00 pm  (Central Europe, Paris, Frankfurt)
8.30 pm  (India)
10.00 am (East Coast US, Boston, New York)
7.00 am  (West Coast USA, LA, San Francisco)

If you are unable to attend on the day, we will be recording the session and will send you a link to the recording and copy of the slides presented. All attendees at the live event will receive a ‘Certificate of Attendance’.