Flipping the Silicon Switch and Healing the Si/C-k: A Novel Strategy in Medicinal Chemistry
Date: 01 December 2020
Time: 15:00 (GMT), 16.00 (CET), 10.00 (ET), 7.00 (PT)
Tutors: Dr John Studley
The introduction of atypical elements in drug design as a novel source of chemical diversity is an interesting concept. The strategic replacement of a carbon atom, particularly a quaternary carbon, with silicon- the so called ‘silicon switch’- can lead to marked differences in the physiochemical and biological properties of the resulting sila-drugs. The fundamental differences between the two atoms, including covalent radii and electronegativity and the ability of silicon to mimic an unstable carbon species such as a hydrated carbonyl have been exploited in number of biologically active molecules and existing and experimental drugs.
This webinar will look in detail at the basic principles underpinning the strategic replacement of carbon with silicon in drug discovery . Case-studies will be used to highlight the key points and synthetic approaches used to target molecules and key intermediates described.
This webinar will be presented by Dr John Studley, Scientific Update and will take place at the following time:
15.00 GMT (UK, Lisbon)
16.00 CET (Paris, Madrid, Frankfurt etc)
10.00 ET (New York, Boston)
7.00 PT (San Francisco, LA)
Please register for FREE using the Book Now button, if you are unable to attend on the day, do not worry, all registrants will be sent links to the recorded session and slides presented afterwards. Registrants who attend the ‘live’ session will receive an e-Certificate of Attendance.