Deuterium in Organic Chemistry and Drug Discovery

Date: 14 November 2018

Time: 15:00 - 16:00

Tutors: Dr John Studley

This FREE to attend webinar will be presented by Dr John Studley, Scientific Update. It will last approx 1 hour starting at:

3.00 pm (UK)
4.00 pm (EU)
10.00 am (New York)

John will cover the following topics:

  • General introduction-, discovery, natural abundance etc
  • Why is deuterium of interest to chemists?
    • Physical properties and comparison to proteo- compounds
    • Applications
    • Key articles to read for further information
  • D2 and D2O
    • Methods of production in the lab and commercial production processes
    • Girdler sulphide process
  • Suppliers of deuterated raw materials intermediates and prices
    • How are deuterated solvents made?
    • Shipping deuterated raw materials
  • Analysis of deuterated organic compounds
    • Mass spec and NMR
    • Isotopic purity
  • Deuterium kinetic isotope effect (examples)
    • Deuterium tracer for reaction mechanism elucidation
  • Deuterium in drug discovery and development
    • Stable isotope labels
    • In vivo effects of deuterium containing compounds (PK/PD effects)
    • Elucidation of metabolic pathways
    • Deuterium in medicinal chemistry- “leaving the label in the drug”
    • Deutetrabenazine- the first FDA approved (2017) deuterated drug (mechanism, benefit)
    • Deuterated Linoleic acid and use of deuterium to reinforce oxidation-vulnerable C-H bonds within nutrients
    • Examples of other deuterated compounds in development
      • Big pharma pipelines
      • Concert pharmaceuticals model
      • Several case studies and examples
    • Regulatory issues
      • FDA 505 (b)(2) and 21 U.S.C. 355(b)(2)
      • Expedited rote to approval
    • Patent issues and obviousness analysis
  • Methods for synthesising deuterium labelled compounds
    • Deuterated reagents (e.g. LiAlD4, LiBD4, NR3.BD3)
    • MacMillan’s photoredox approach to deuterated API’s
    • C-H functionalization approaches
    • Metal-mediated approaches
      • Alpha-deuteration of amino acids and amines at scale
    • Incorporation of deuterium into heterocycles
  • Introduction to the use of Tritium
  • Short introduction to other isotopes- C13, C14, N15 and radio-isotopes

 

 

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