Taming High-Energy Molecules Across Multiple Unit Operations

The reported case study is about the development and improvement of a process for the synthesis of a highly energetic small molecule and its purification. Several safety issues were identified and found to impact different unit operations (hot filtration, drying, recrystallization…): this could be done by approaching the safety studies as an integral part of the process development work, as opposed to an isolated step required prior to industrialization. In particular, a combined approach of process safety, modelling and Design of Experiments (DoE) studies, as well as the use of in-process monitoring of critical parameters by meaning of in-line analysis (FTIR and imaging), is described. This work shows how, by applying a thorough and methodical work-flow, the optimal safe envelop to conduct large-scale synthesis can be built.

This presentation is aimed at process chemists, and chemical engineers and anyone with an interest in process safety.

This webinar was presented by Dr Margherita Pirola from OLON SpA and was kindly sponsored by Mettler-Toledo.