VIRTUAL TRAINING EVENT | Secrets of Batch Process Scale-Up
On line Training Course
Date: 09 November - 13 November 2020
Location: On-Line Event
Tutors: Francis X. McConville
This popular course has gone VIRTUAL!, it will be divided into five sections, over five days – please see the timings and dates below:
Monday, November 9th | 1.30 – 5.30pm BST
Tuesday, November 10th | 1.30 – 4.30pm BST
Wednesday, November 11th | 1.30 – 5.30pm BST
Thursday, November 12th | 1.30 – 4.30pm BST
Friday, November 13th | 1.30 – 5.30pm BST
This course is designed for those with limited or no pilot plant or scale-up experience, provides a comprehensive overview of the most common problems experienced during the scale up of laboratory batch processes, and ways to avoid or mitigate them. The difference between laboratory scale techniques and how the major unit operations are carried out in the pilot plant is a key focus of the course. Thus, along the way attendees will examine the many issues associated with raw material handling, conducting synthetic reactions, reaction workup, product crystallization, isolation and drying at the pilot plant or commercial scale.
The course also explores some important engineering concepts such as batch mixing, heat transfer, mass transfer, fluid flow and the influence of these factors on the success of large scale chemical operations. With an awareness of these phenomena, the laboratory researcher will have a better understanding of the types of experiments that should be conducted and the types of data that should be collected to ensure a more successful scale-up. Numerous examples and case histories are presented to reinforce the course material, and class exercises provide an opportunity to put some of the lessons into practice. Heavy emphasis is placed on process safety.
For those that still wish to attend the course LIVE, we have dates booked in for 2021 (subject to the current Covid-19) situation, see below for dates and links.
Download Brochure Booking Form
|Process Design for Scale-Up
Process development strategies
Importance of engineering in PDs
Scale-Up – An Overview
Following Reaction Progress
|Agitation and Mixing
Large scale mixing equipment
Mixing limited reaction
Mixing scale-up / scale-down
Quench & Work-Up
Phase continuity issues and emulsions
Distillation & Stripping
Azeotropes and solvent exchange
Crystallization and Precipitation
Basic principles / yield estimation
Product Isolation and Drying
Large-scale solid-liquid separations
Filtration and drying equipment
Filtration and drying modelling
Process Hazards and Safety Assessment
Common hazards in large-scale processing
Process hazard assessments and evaluations
Benefits of attending
On completion of this course you will be able to:
- Assess the safety and scalability of new processes
- Identify process operations that may be problematic on scale-up
- Design processes that will minimize or avoid common scale-up issues
- Better understand heat transfer and mixing requirements for scale-up
- Develop more robust crystallization, isolation and drying processes
Who should attend
This course has been designed for chemists, engineers, technicians and managers in the fine chemical and pharmaceutical industries with limited pilot plant experience who wish to learn more about the potential pitfalls of process scale-up and ways to avoid them. Attendees will come away from the course more knowledgeable about common scale-up problems and better equipped to prepare for and deal with them. The course complements the more chemistry-focused Scientific Update course “Chemical Development and Scale-Up in the Fine Chemical and Pharmaceutical Industries”.
The course fee includes:
- link to watch all five sessions
- course certificate
For this on line course, please note no PDF versions of the slides will be shared via email, you will have the opportunity of purchasing a hard copy of the manual in advance and a copy of the Pilot Plant book (at a special price).
Manual = £120.00 including postage
Pilot Plant book = £90.00 (normally £140.00)
Very well presented, gave me a glimpse into the complexity of chemical engineering and how much is possible when transferring a process to the plant.
Francis is a very good tutor, using his experience to clearly explain all aspects of scale-up while giving practical tips and tools based on real life situations in production.
I have three colleagues who have attended the training a few years ago and they only had positive things to say about the event. I sure would have liked to be there in person, but Mr. McConville still manages to make it very interesting despite the distance. I’m looking forward to tomorrow!