VIRTUAL TRAINING EVENT | Biocatalysis – Solving Scale-Up Issues with Biocatalysed Reactions

Date: 15 July - 16 July 2020

Location: On-Line Event

Tutors: Dr Andrew Wells

This is a VIRTUAL short course will look at biocatalysed/biotransformation reactions to make pharma/agro chem intermediates, API’s and fine chemicals. the focus is on scale-up issues and getting productive process established.

July 15, 1.30 – 4.30 pm (UK)  |  Session 1

July 16, 1.30 – 4.30 (UK) |  Session 2

Many forays by organic chemists into using biocatalysis in chemical synthesis stall at the initial scale-up stage. Screening and small scale (gram) reactions progress as planned, but when scaled -up, reactions stall, take more enzyme than expected, work-ups end up with emulsion issues etc. This course will look at some of the techniques and technologies ( tricks of the trade) that can help derisk scaling up biocatalysed reactions .A further barrier to the adoption of more biocatalytic reactions are production / EHS scientists who are unsure how to handle enzymes in the plant/pilot plant. the course will also look at good sources of information/data to facilitate the use of enzymes at scale.

  • Enzyme supply chain: Storage, stability etc
  • Techno-economic analysis – will the transformation ever hit the required targets?
  • Different types of strains used and its safety impactions.
  • Using GMO’s and GMO derived materials
  • Handling concerns related to enzyme -SHE/EHS issues., Safety issues in scaling up biocatalytic reactions
  • Pros and cons of different enzyme formulations
  • Enzyme stability: General to pH, co-solvent, temperature as linked to process design and development
  • Enzyme analysis / characterisation – needed to assess purity in order to calculate activity and so expected long term cost, spec setting / quality control (ensure plant samples match lab samples and measure variation over time).
  • Scale-up – reactor options – various reactor types, std batch, continuous, membrane separated, continuous liquid extraction, etc
  • Product isolation from complex mix . Enzyme removal/ downstream processing– to be intelligent in terms of what can and can’t be removed vs effects on process including downstream chemistry.
  • Use of immobilised enzymes/ Recycling of immobilised enzymes
  • Some IP considerations

When you register you will be sent links to join the on-line sessions. These will take place at the following time each day:

1.30 – 4.30 pm  |  UK

2.30 – 5.30  |  Central Europe

08.30 – 11.30 |  Eastern US

5.30 – 8.30 am  |  West Coast US

As space is limited there is a small charge of £195.00 + VAT* per person (*only added if your company is based in the UK) Payments only available via credit card.

Book Now

Remind Me


Booking Form
×

Remind me about this course

We'll remind you a month before this course starts or if we're running out of spaces. Enter your email address below.

Who should attend?

This online class will be of interest to anyone who are:

Scientists working in medicinal/process chemistry and are interested in moving from mg/screening scale to 100’ s grams-multi kg scale

Please note: this course assumes some prior existing knowledge of biocatalysis / biotransformations as applied to synthetic organic chemistry, either in theory or some prior practical use at screening/ small scale laboratory experimentation, an appreciation of different enzyme classes etc.

Testimonials

Virtual Delegate 2020

I really enjoyed the virtual Short Course and it was very good incl. the thorough collection of examples etc.

Looking forward to the next ones!