Transition-Metal Catalysis in the Pharma Industry: An Indispensable Tool

31 March 2025 - 08 April 2025
Online Event
Spaces available

Event overview

Course tutors: Dr Vittorio Farina

NEW COURSE

Over 50% of recently published API syntheses contain at least one transition-metal-catalysed step. Not being familiar with the newer synthetic and mechanistic developments in transition-metal catalysis may severely limit a process chemist’s toolbox.

This course will cover the key principles of catalysis and the basic chemistry of transition metals needed to understand typical catalytic cycles. The course will then describe in detail the reactions which are most useful in the pharma industry today. For each reaction, a basic mechanistic discussion will be presented, followed by a discussion of the synthetic scope and potential side processes. Practical suggestions on how to approach and successfully scale up these reactions will be provided, supplemented by recently published case studies.

Finally, the course will describe important new tools which will probably be embraced by the industry in the next decade and will provide resources for further reading.

The course will conclude with an open problem session, designed to enhance attendee participation and reinforce the notions learned.

 

We are delighted to provide this NEW online course, it will be divided up into four sessions using an online platform.  Dates and times are as follows and set in UK Time (British Summer Time):

Monday, March 31 | 2.00 – 5.00pm BST
Tuesday, April 1 | 2.00 – 5.00pm BST
Monday, April 7 | 2.00 – 5.00pm BST
Tuesday, April 8 | 2.00 – 5.00pm BST

Course Outline

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  • The growing role of transition-metal catalysis in the pharmaceutical industry.
  • Brief introduction to the field of homogeneous catalysis.
  • Basic concepts: turnover frequency, turnover number, catalyst resting state, rate-determining step.
  • Frequently encountered scale-up problems.
  • The key reactions of transition-metal complexes.
  • The most useful and general catalytic reactions in API synthesis: scope, mechanism, limitations and potential side products.
  • Classical C-C cross coupling reactions (Suzuki, Negishi, Stille, Hiyama, Sonogashira).
  • The Heck olefination reaction.
  • C-N cross coupling: the Buchwald-Hartwig amination and related chemistry.
  • Complex operations involving both C-C and C-N bond formation.
  • Methodology based on C-H activation.
  • Homogeneous hydrogenation of C=C, C=O and C=N bonds. Enantioselective versions.
  • Metal-catalyzed borylation reaction.
  • The Tsuji-Trost reaction and other allylic substitution reactions.
  • Enantioselective epoxidations and dihydroxylations.
  • Olefin metathesis and related reactions.
  • Carbonylation reactions.
  • Application of Wacker chemistry.
  • Upcoming methodologies: resources for further reading.
  • Open discussion of problems.

Benefits of Attending

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After this course, the attendees will be able to introduce transition-metal catalysis into their processes with more confidence. Also, they will be able to troubleshoot existing methodology with more mechanistic insight. The practical suggestions will help avoid common errors in applying these methodologies.

Who Should Attend?

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The course is suited to any process chemist who would like to become more proficient in applying basic organometallic chemistry in API processes but has limited practical experience or has not followed the field for some time and lacks a general perspective of how this chemistry has evolved in the last few decades. The course is also useful to medicinal chemists who may want to refresh their knowledge of this rapidly evolving field.

What's Included

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Other Information

Discounts

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1st delegate fee = Full price
2nd delegate fee = 5% off
3rd delegate fee = 10% off
4 or more delegate fees = 15% off

For more information on discounts do give us a call on +44 (0) 1892 956 222

What's Included?

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The course fee includes:

  • Link to watch all four live sessions
  • Electronic version of the course manual*
  • Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.

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Transition-Metal Catalysis in the Pharma Industry: An Indispensable Tool

31 March 2025 - 08 April 2025
Online Event