Archived: Safety & Selectivity in the Scale-Up of Chemical Reactions

Date: 17 April - 20 April 2023

Location: Online Platform

Tutors: Dr John Studley

We are delighted to be able to offer this course now ONLINE, this two-day course will be divided up into four sessions using an online platform, dates and times are as follows and set in BST (British Summer Time):

Monday 17 April  | 2.00pm – 5.00pm BST
Tuesday 18 April | 2.00pm – 5.00pm BST
Wednesday 19 April 
| 2.00pm – 5.00pm BST
Thursday 20 April  | 2.00pm – 5.00pm BST

The safety of chemical processes is critical for the whole chemical industry. It is vital that process development chemists and engineers are able to identify aspects of the chemistry that may be hazardous or pose a risk to the safety of the process or equipment.

In order to do this, they need to know when to proactively engage colleagues or contractors to carry out process safety testing and hazard analysis, which in turn requires a knowledge of the equipment and test methods available.

As chemical reactions are scaled up and operations become more economic the ability to remove heat from exothermic events becomes reduced and at the same time the outcome of any incident becomes much more severe.

This is an almost unique course on the safety of chemical reactions and processes that are designed by chemists for chemists (and engineers) with the ultimate aim of helping the chemical industry reduce the number of chemical or process related incidents.

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Course Outline

The aim of the course is to give lab chemists an understanding of the issues that need to be considered during the early stages of scale up to large laboratory scale equipment (10-20 litre vessels) / kilo lab. The course will concentrate on chemical safety and selectivity issues and include information on what safety testing equipment is available and the uses and limitations of this equipment. Attendees will learn how to identify potential problems whether they be thermal hazards or selectivity issues. Methods used by other companies for handling hazardous reagents and reactions will be described as well as alternative chemistry to circumvent these reactions and/or reagents.

Benefits of Attending

  • Attendees will learn how to identify potentially unsafe chemical processes, particularly those that pose more a danger on scale
  • They will learn about what testing procedures are available to help them identify unsafe operating conditions to enable to talk knowledgably to in-house safety professionals or contract organizations
  • Sources of safety information in the literature and via the internet will be provided
  • The course provides lists of reagents and functional groups that should trigger safety testing studies
  • Methods used in other companies for handling hazardous reagents and reactions will be provided
  • Alternatives reagents or substitutes for hazardous materials will also be discussed
  • Recommendations will be provided for making the first sample of a product where there may be safety or stability concern


Who Should Attend

Any laboratory chemist involved in the scale-up to large scale equipment/kilo lab

What's Included

he course fee includes:

  • Link to watch all four live sessions
  • Electronic version of the course manual*
  • Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.


Online Merck Delegate

Both registration and connection to the online platform were very good.

The course was interesting with many examples from industry. Good balance between theoretical and practical information. The lecturers were professional and presented in a clear and understandable way.

Online Purolite Ltd Delegate

A really great course providing a good understanding for people to evaluate and safely scale up their reactions.

Online Safety & Selectivity Delegate 2021

Great experience, I learned a lot and despide it was online everything was well provided by Scientific Update.

Online Safety & Selectivity Delegate 2021

Both John and Will did great job teaching the content! The manual is nicely structured in topics, start with general issues and recommendation, then details in case studies from publication that’s really up to date.