Archived: Organometallic Chemistry from Magnesium to Palladium

Date: 08 November - 09 November 2018

Location: Nice, France

Tutors: Dr Will Watson

This course will cover stoichiometric organometallics such as Grignard reagents and catalytic organometallics based mainly on palladium and other platinum group metals.
The first day will concentrate on Grignard reagents and organolithiums and organozincs including preparation and uses and safety aspects of these reagents. Catalytic C-C and C-X bond forming reactions will be covered on day 2, concentrating on palladium catalysis, but with discussion of systems using other metals such as copper, nickel, ruthenium, rhodium and iridium. Throughout the course the emphasis will be on practical methods of carrying out synthetically useful reactions. Many case studies and industrial examples will be included to illustrate the utility of both catalytic and stoichiometric organometallic reactions.

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Course Outline

Day 1: Stoichiometric Organometallic Reagents

  1. Introduction; Bonding, reactivity
  2. Making and Handling Organolithiums, Grignards and Organozincs, Metal halogen exchange, Directed metalation
  3. Safety Issues, Stability of reagents and intermediates, Exotherms and potential runaways
  4. Using Grignard reagents, Case studies using organomagnesium reagents
  5. Recent developments in Grignard Chemistry, New chemistry and new technology using Grignard reagents
  6. Organolithium and organozinc reagents

 

Day 2: Catalytic Organometallic Reagents

  1. Introduction; Metals, Ligands, Catalytic cycles
  2. Metal catalysed C-C bond forming reactions, Biaryl coupling reactions and Heck reactions, Aromatic cyanation, Hydroformylation
  3. Metal catalysed C-X bond forming reactions, Buchwald-Hartwig Coupling, Migita Coupling, Other C-X bond forming reactions
  4. Other transition metal catalysed reactions (Rh, Ru, Ir, and Au); Asymmetric C-C bond formation, Borrowing hydrogen chemistry, Hydrogen mediated bond forming reactions
  5. Catalysis with cheaper metals (Ni, Cu, Fe, Co), Ni and Cu as alternatives to Pd, Fe and Co catalysed reactions
  6. Industrial Case Studies and Scale Up

Who Should Attend

Process Chemists wishing to maximise their knowledge and understanding of the chemical technology
Discovery Chemists wishing to keep their industrial synthetic chemistry know-how at the cutting edge
Production Chemists wishing to maintain their awareness of emerging industrial chemical technologies
Experienced Chemists looking to refresh and/or augment their knowledge of industrial Organometallic Chemistry
Students who are about to enter industry
New Starters who have just started work in industry as organic chemists
Managers who might benefit from an overview of the chemical technology available for use in the pharmaceutical, fine chemical and allied industries today

What's Included

The course fee includes:

  • comprehensive course manual
  • coffee/tea refreshments breaks throughout each day
  • buffet lunch each day
  • course dinner on the first evening
  • course certificate