Organofluorine Chemistry: Synthesis, Applications, Sources and Sustainability
Event overview
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| New Course for 2020 |
Organofluorine compounds are frequently encountered in the pharmaceutical, agrochemical and fine chemical industries. Often the selective introduction of a fluorine atom or functional group into a molecule can be challenging, particularly at scale, with chemists often designing synthetic routes in which fluorine is introduced through strategic sourcing of raw materials rather than synthetically.
This two-day course aims to provide an overview of fluorination technology and synthetic methods- both traditional and state of the art- highlighting industrial application. Detailed case studies are used to provide context and workshops enable delegates to familiarize themselves with the chemistry described.
Course Outline
Introduction
- Unique properties of fluorine
- Historical context
- Sources of fluorine
- Handling and toxicity
Methods of introducing fluorine
- Aromatic and heteroaromatic fluorination
- Nucleophilic and electrophilic fluorinating reagents
- Aliphatic fluorination
- Heterocyclic fluorination
- Radical methods, photoredox and electrochemistry
- Large scale application of fluorination methods
Fluorinated functional groups
- Trifluoromethylation, difluoromethylation, monofluoromethylation
- Fluoroalkenes
- SF3, SF5
- -OCF3, OCHF2, OCH2F
- Perfluoroalkyl
Miscellaneous fluorination methods
- Fluorination of enolates and organometallics
- Biocatalytic methods
- Hydrodefluorination
- Asymmetric fluorination
- Late stage fluorination
Fluorine in medicinal chemistry and agrochemicals
- Role of fluorine in drugs and agrochemicals and natural products
- Fluorinated drugs
- Fluorinated amino acids and proteins
- 18F and PET
Fluorinated building blocks, synthons and materials
- Liquid crystals and optoelectronics
- Fluorine containing organocatalysts
- Fluorinated solvents
Benefits of Attending
- An extensive review of synthetic organofluorine chemistry and its application in the synthesis of pharmaceuticals, agrochemicals and fine chemicals.
- Learn how and when to incorporate fluorine in a synthetic route.
- Information on fluorine containing building blocks and commercial synthons.
- An understanding of the processes involved in the development and scale-up of fluorination chemistry.
- An appreciation of the role of fluorine in medicinal chemistry
Who Should Attend
Discovery/Synthetic organic chemists
Process development chemists
Anyone wishing to learn more about organofluorine chemistry
What's Included
The course fee includes:
- comprehensive course manual
- coffee/tea refreshments breaks throughout each day
- buffet lunch each day
- course dinner on the first evening
- course certificate
Other Information
General Information
Each course includes:
- Refreshments & lunch daily
- Dinner on the first evening*
- The comprehensive Course Manual
- Course Certificate
Please refer to the course brochure for detailed timings.
*Not every course includes dinner please refer to the course brochures for detailed information on what’s included.
Course Certificate
At the end of each course participants receive a Certificate of Attendance – signed by your tutor.
Accommodation
Depending on venues we either reserve a limited number of bedrooms at a special rate for you or we will provide a list of recommended hotels close by to the course venue. More information on rates and booking forms will be provided upon booking. All rooms will need to booked directly with the hotel.
Discounts
1st delegate = full price
2nd delegate = 5% off
3rd delegate = 10% off
4 or more delegates = 15% off
For more information on discounts do give us a call on 44 1435 873 062
Venue info
Clearwater Beach
Florida 33767
USA
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