Organofluorine Chemistry: Synthesis, Applications, Sources and Sustainability

A 2 day training course

Date: 12 March - 13 March 2020

Location: Clearwater, USA

New Course for 2020

Organofluorine compounds are frequently encountered in the pharmaceutical, agrochemical and fine chemical industries. Often the selective introduction of a fluorine atom or functional group into a molecule can be challenging, particularly at scale, with chemists often designing synthetic routes in which fluorine is introduced through strategic sourcing of raw materials rather than synthetically.

This two-day course aims to provide an overview of fluorination technology and synthetic methods- both traditional and state of the art- highlighting industrial application. Detailed case studies are used to provide context and workshops enable delegates to familiarize themselves with the chemistry described.

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Course Outline

Introduction

  • Unique properties of fluorine
  • Historical context
  • Sources of fluorine
  • Handling and toxicity

 

Methods of introducing fluorine

  • Aromatic and heteroaromatic fluorination
  • Nucleophilic and electrophilic fluorinating reagents
  • Aliphatic fluorination
  • Heterocyclic fluorination
  • Radical methods, photoredox and electrochemistry
  • Large scale application of fluorination methods

 

Fluorinated functional groups

  • Trifluoromethylation, difluoromethylation, monofluoromethylation
  • Fluoroalkenes
  • SF3, SF5
  • -OCF3, OCHF2, OCH2F
  • Perfluoroalkyl

 

Miscellaneous fluorination methods

  • Fluorination of enolates and organometallics
  • Biocatalytic methods
  • Hydrodefluorination
  • Asymmetric fluorination
  • Late stage fluorination

 

Fluorine in medicinal chemistry and agrochemicals

  • Role of fluorine in drugs and agrochemicals and natural products
  • Fluorinated drugs
  • Fluorinated amino acids and proteins
  • 18F and PET

 

Fluorinated building blocks, synthons and materials

  • Liquid crystals and optoelectronics
  • Fluorine containing organocatalysts
  • Fluorinated solvents

Benefits of Attending

  • An extensive review of synthetic organofluorine chemistry and its application in the synthesis of pharmaceuticals, agrochemicals and fine chemicals.
  • Learn how and when to incorporate fluorine in a synthetic route.
  • Information on fluorine containing building blocks and commercial synthons.
  • An understanding of the processes involved in the development and scale-up of fluorination chemistry.
  • An appreciation of the role of fluorine in medicinal chemistry

Who Should Attend

Discovery/Synthetic organic chemists

Process development chemists

Anyone wishing to learn more about organofluorine chemistry

What's Included

The course fee includes:

  • comprehensive course manual
  • coffee/tea refreshments breaks throughout each day
  • buffet lunch each day
  • course dinner on the first evening
  • course certificate