Archived: Organofluorine Chemistry: Synthesis, Applications, Sources and Sustainability
A 2 day training course
Date: 12 March - 13 March 2020
Location: Clearwater, USA
Tutors: Dr John Studley
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|New Course for 2020|
Organofluorine compounds are frequently encountered in the pharmaceutical, agrochemical and fine chemical industries. Often the selective introduction of a fluorine atom or functional group into a molecule can be challenging, particularly at scale, with chemists often designing synthetic routes in which fluorine is introduced through strategic sourcing of raw materials rather than synthetically.
This two-day course aims to provide an overview of fluorination technology and synthetic methods- both traditional and state of the art- highlighting industrial application. Detailed case studies are used to provide context and workshops enable delegates to familiarize themselves with the chemistry described.
- Unique properties of fluorine
- Historical context
- Sources of fluorine
- Handling and toxicity
Methods of introducing fluorine
- Aromatic and heteroaromatic fluorination
- Nucleophilic and electrophilic fluorinating reagents
- Aliphatic fluorination
- Heterocyclic fluorination
- Radical methods, photoredox and electrochemistry
- Large scale application of fluorination methods
Fluorinated functional groups
- Trifluoromethylation, difluoromethylation, monofluoromethylation
- SF3, SF5
- -OCF3, OCHF2, OCH2F
Miscellaneous fluorination methods
- Fluorination of enolates and organometallics
- Biocatalytic methods
- Asymmetric fluorination
- Late stage fluorination
Fluorine in medicinal chemistry and agrochemicals
- Role of fluorine in drugs and agrochemicals and natural products
- Fluorinated drugs
- Fluorinated amino acids and proteins
- 18F and PET
Fluorinated building blocks, synthons and materials
- Liquid crystals and optoelectronics
- Fluorine containing organocatalysts
- Fluorinated solvents
Benefits of Attending
- An extensive review of synthetic organofluorine chemistry and its application in the synthesis of pharmaceuticals, agrochemicals and fine chemicals.
- Learn how and when to incorporate fluorine in a synthetic route.
- Information on fluorine containing building blocks and commercial synthons.
- An understanding of the processes involved in the development and scale-up of fluorination chemistry.
- An appreciation of the role of fluorine in medicinal chemistry
Who Should Attend
Discovery/Synthetic organic chemists
Process development chemists
Anyone wishing to learn more about organofluorine chemistry
The course fee includes:
- comprehensive course manual
- coffee/tea refreshments breaks throughout each day
- buffet lunch each day
- course dinner on the first evening
- course certificate