Organofluorine Synthesis and Application: Strategies and Industrial Implementation
Online Training Course
Event overview
Organofluorine compounds are frequently encountered in the pharmaceutical, agrochemical and fine chemical industries. Often the selective introduction of a fluorine atom or functional group into a molecule can be challenging, particularly at scale, with chemists often designing synthetic routes in which fluorine is introduced through strategic sourcing of raw materials rather than synthetically.
This online course aims to provide an overview of fluorination technology and synthetic methods- both traditional and state of the art- highlighting industrial application. Detailed case studies are used to provide context and workshops enable delegates to familiarize themselves with the chemistry described.
The course will take place over two afternoon sessions, timings are all set in BST (British Summer Time);
Tuesday, September 23rd | 2.00 – 5.30pm UK
Wednesday, September 24th | 2.00 – 5.30pm UK
Course Outline
Introduction
- Unique properties of fluorine
- Historical context
- Sources of fluorine
- Handling and toxicity
Methods of introducing fluorine
- Aromatic and heteroaromatic fluorination
- Nucleophilic and electrophilic fluorinating reagents
- Aliphatic fluorination
- Heterocyclic fluorination
- Radical methods, photoredox and electrochemistry
- Large scale application of fluorination methods
Fluorinated functional groups
- Trifluoromethylation, difluoromethylation, monofluoromethylation
- Fluoroalkenes
- SF3, SF5
- -OCF3, OCHF2, OCH2F
- Perfluoroalkyl
Miscellaneous fluorination methods
- Fluorination of enolates and organometallics
- Biocatalytic methods
- Hydrodefluorination
Fluorine in medicinal chemistry and agrochemicals
- Role of fluorine in drugs and agrochemicals and natural products
- Fluorinated drugs
Benefits of Attending
- An extensive review of synthetic organofluorine chemistry and its application in the synthesis of pharmaceuticals, agrochemicals and fine chemicals.
- Learn how and when to incorporate fluorine in a synthetic route.
- Information on fluorine containing building blocks and commercial synthons.
- An understanding of the processes involved in the development and scale-up of fluorination chemistry.
- An appreciation of the role of fluorine in medicinal chemistry
Who Should Attend
Discovery/Synthetic organic chemists
Process development chemists
Anyone wishing to learn more about organofluorine chemistry
Other Information
What's Included
The course fee includes:
- all live sessions of the course
- course certificate at the end
- e-reader version of the manual
You will have the option of obtaining a hard copy of the manual and this will be sent via the post to you and has an additional postage cost. Please note recordings of any sessions will not be shared.
Special Offers
1st delegate fee = Full price
2nd delegate fee = 5% off
3rd delegate fee = 10% off
4 or more delegate fees = 15% off
For more information on offers, do give us a call on +44 (0) 1892 956 222
Course Certificate
Upon completion of the course, participants can request a Certificate of Attendance.
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