Organofluorine Chemistry: Synthesis, Applications, Sources and Sustainability
Event overview
We are delighted to present this two day course On Line and will be divided up over three afternoon sessions, timings are all set in GMT (Greenwich Meantime) and are set later to help with our international clients.
July 19th, 2023 | 2.00 – 5.30pm UK
July 20th, 2022 | 2.00 – 5.30pm UK
July 21st, 2022 | 2.00 – 5.30pm UK
Organofluorine compounds are frequently encountered in the pharmaceutical, agrochemical and fine chemical industries. Often the selective introduction of a fluorine atom or functional group into a molecule can be challenging, particularly at scale, with chemists often designing synthetic routes in which fluorine is introduced through strategic sourcing of raw materials rather than synthetically.
This on line course aims to provide an overview of fluorination technology and synthetic methods- both traditional and state of the art- highlighting industrial application. Detailed case studies are used to provide context and workshops enable delegates to familiarize themselves with the chemistry described.
Please do view the brochure for more information (please note this is based on the live 2 day course, but the content is the same)
Course Outline
Introduction
- Unique properties of fluorine
- Historical context
- Sources of fluorine
- Handling and toxicity
Methods of introducing fluorine
- Aromatic and heteroaromatic fluorination
- Nucleophilic and electrophilic fluorinating reagents
- Aliphatic fluorination
- Heterocyclic fluorination
- Radical methods, photoredox and electrochemistry
- Large scale application of fluorination methods
Fluorinated functional groups
- Trifluoromethylation, difluoromethylation, monofluoromethylation
- Fluoroalkenes
- SF3, SF5
- -OCF3, OCHF2, OCH2F
- Perfluoroalkyl
Miscellaneous fluorination methods
- Fluorination of enolates and organometallics
- Biocatalytic methods
- Hydrodefluorination
- Asymmetric fluorination
- Late stage fluorination
Fluorine in medicinal chemistry and agrochemicals
- Role of fluorine in drugs and agrochemicals and natural products
- Fluorinated drugs
- Fluorinated amino acids and proteins
- 18F and PET
Fluorinated building blocks, synthons and materials
- Liquid crystals and optoelectronics
- Fluorine containing organocatalysts
- Fluorinated solvents
Benefits of Attending
- An extensive review of synthetic organofluorine chemistry and its application in the synthesis of pharmaceuticals, agrochemicals and fine chemicals.
- Learn how and when to incorporate fluorine in a synthetic route.
- Information on fluorine containing building blocks and commercial synthons.
- An understanding of the processes involved in the development and scale-up of fluorination chemistry.
- An appreciation of the role of fluorine in medicinal chemistry
Who Should Attend
Discovery/Synthetic organic chemists
Process development chemists
Anyone wishing to learn more about organofluorine chemistry
What's Included
The course fee includes:
- all three sections of the course
- course certificate at the end
- e-reader version of the manual
You will have the option of obtaining a hard copy of the manual and this will be sent via the post to you and has an additional postage cost. Please note recordings of any sessions will not be shared.
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