Modern Synthetic Organic Reactions
Event overview
Driven by the increasing complexity of synthetic targets and the need for efficient, selective and environmentally benign synthetic methods, the past decade has seen tremendous innovation and reaction understanding in the field of synthetic organic chemistry. However, much like the transition of a molecule from discovery to development, the transition and application of new synthetic methodology from a research setting to an industrially relevant context can be challenging. This course is designed to look in detail at essential new synthetic chemistry methodology and its potential application in addressing key challenges in industry. New processes will be presented with case studies and examples. In addition, an understanding of what it takes to transfer technology from an academic to a larger scale industrial context will be discussed.
Course Outline
Course Overview:
Photoredox
- Photoinduced electron transfer chemistry
- Photoredox catalysts- synthesis, properties and tuning
- Application and scale-up
C-H Functionalisation
- Aromatic C-H functionalisation
- Aliphatic C-H functionalisation
- C-H coupling with halides and pseudohalides
- C-H – C-H coupling
Hypervalent iodine
- Oxidation with hypervalent iodine reagents
- Rearrangements mediated by hypervalent iodine reagents
- C-C and C-X bond formation mediated by hypervalent reagents
Electrochemistry
- Synthetic organic electrochemistry
- Electrochemical redox processes
- Applications, setup and getting started
Hydrogen Mediated Reactions and Borrowing Hydrogen Chemistry
- C-C and C-X bond formation via borrowing hydrogen
- Using alcohols in place of halides and pseudohalides
- Hydrogen mediated C-C bond formation (Krische chemistry)
Organocatalysis
- Organocatalysis v’s transition metal processes
- Catalyst classes and reaction examples
- Asymmetric transformations
Biocatalysis
- Recent developments in biocatalysis
- Directed evolution of enzymes
- “Non-natural” reactions catalysed by modified enzymes
Catalysis with Cheaper Metals
- Green chemistry and sustainability
- Base metals in cross coupling, hydrogenation and cyclization chemistry
- New applications of base metals in industrial organic chemistry
Borylation and Organoboron Chemistry
- Preparation of boronic acids and other boronate reagents
- Rearrangements involving organoboron species (e.g. Matteson Reaction)
Case studies
- Industrial examples involving the use of the chemistry discussed during the course
Benefits of Attending
- A forward-looking review of how new technology and synthetic methods will shape the future of industrial organic synthesis.
- A comprehensive overview of new synthetic methodology and its potential application in the synthesis of pharmaceuticals, agrochemicals and fine chemicals.
- Gain a different perspective on solving synthetic challenges in your chemistry.
- An appreciation of the factors that need to be considered in transferring new synthetic chemistry from an academic to an industrial setting.
Who Should Attend
- Discovery/Synthetic organic chemists
- Process development chemists
- Anyone wishing to learn more about essential new synthetic chemistry methodology and its potential application in an industrial setting
- Academics who wish to understand how industrial and process chemists view new synthetic chemistry and what can be done at the discovery stage to make the technology scalable.
What's Included
The course fee includes:
- comprehensive course manual
- coffee/tea refreshments breaks throughout each day
- buffet lunch each day
- course dinner on the first evening
- course certificate
Other Information
General Information
Each course includes:
- Refreshments & lunch daily
- Dinner on the first evening*
- The comprehensive Course Manual
- Course Certificate
Please refer to the course brochure for detailed timings.
*Not every course includes dinner please refer to the course brochures for detailed information on what’s included.
Course Certificate
At the end of each course participants receive a Certificate of Attendance – signed by your tutor.
Accommodation
Depending on venues we either reserve a limited number of bedrooms at a special rate for you or we will provide a list of recommended hotels close by to the course venue. More information on rates and booking forms will be provided upon booking. All rooms will need to booked directly with the hotel.
Discounts
1st delegate = full price
2nd delegate = 5% off
3rd delegate = 10% off
4 or more delegates = 15% off
For more information on discounts do give us a call on 44 1435 873 062
Venue info
28006 Madrid,
Spain
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