Modern Synthetic Organic Reactions

Course Overview:

Photoredox

• Photoinduced electron transfer chemistry
• Photoredox catalysts- synthesis, properties and tuning
• Application and scale-up

C-H Functionalisation

• Aromatic C-H functionalisation
• Aliphatic C-H functionalisation
• C-H coupling with halides and pseudohalides
• C-H – C-H coupling

Hypervalent iodine                                                                                                          WW

• Oxidation with hypervalent iodine reagents
• Rearrangements mediated by hypervalent iodine reagents
• C-C and C-X bond formation mediated by hypervalent reagents

Electrochemistry                                                                                                              JS

• Synthetic organic electrochemistry
• Electrochemical redox processes
• Applications, setup and getting started

Hydrogen Mediated Reactions and Borrowing Hydrogen Chemistry

• C-C and C-X bond formation via borrowing hydrogen
• Using alcohols in place of halides and pseudohalides
• Hydrogen mediated C-C bond formation (Krische chemistry)

Organocatalysis

• Organocatalysis v’s transition metal processes
• Catalyst classes and reaction examples
• Asymmetric transformations

Biocatalysis                                                                                                                         WW

• Recent developments in biocatalysis
• Directed evolution of enzymes
• “Non-natural” reactions catalysed by modified enzymes

Catalysis with Cheaper Metals                                                                                    JS

• Green chemistry and sustainability
• Base metals in cross coupling, hydrogenation and cyclization chemistry
• New applications of base metals in industrial organic chemistry

Borylation and Organoboron Chemistry

• Preparation of boronic acids and other boronate reagents
• Rearrangements involving organoboron species (e.g. Matteson Reaction)

Case studies                                                                                                                       WW

• Industrial examples involving the use of the chemistry discussed during the course

• A forward-looking review of how new technology and synthetic methods will shape the future of industrial organic synthesis.
• A comprehensive overview of new synthetic methodology and its potential application in the synthesis of pharmaceuticals, agrochemicals and fine chemicals.
• Gain a different perspective on solving synthetic challenges in your chemistry.
• An appreciation of the factors that need to be considered in transferring new synthetic chemistry from an academic to an industrial setting.

• Discovery/Synthetic organic chemists
• Process development chemists
• Anyone wishing to learn more about essential new synthetic chemistry methodology and its potential application in an industrial setting
• Academics who wish to understand how industrial and process chemists view new synthetic chemistry and what can be done at the discovery stage to make the technology scalable.

The course fee includes:

• all six sections of the course
• course certificate at the end

You will have the option of buying a hard copy of the manual and this will be sent via the post to you.  Please note for on line courses no PDF version of the slides/manual will be sent via email and no recordings are available after the event.   Please note recordings of any sessions will not be shared.