Medicinal Chemistry

02 June 2025 - 06 June 2025
Online Event
Spaces available

Event overview

Course tutors: Dr David Clark, Dr Martin Swarbrick, Dr Paul Beswick , Dr Rachael White, Dr John Studley

Medicinal chemists need to understand the relationship between chemical structure and the physical properties of molecules and how this translates into compound stability and the interaction of the molecule with biological structures.  These biological targets include proteins, lipids, nucleic acids and cell membranes.  Interaction of the molecules with these targets affects the distribution of the compound in biological systems and modulates biological function.

To do this successfully the medicinal chemist needs to be aware of how target selection is carried out and how this effects lead generation.  The medicinal chemist needs knowledge of structure property relationships, the physico-chemical properties of drugs and how these molecules interact with the body– pharmacokinetics and ADME (Absorption, Distribution, Metabolism and Excretion).

The course also includes an overview of the use of computational chemistry in virtual screening and library design.  The lectures are backed up by a number of case studies and tutorial sessions, which involve the participants in using the concepts discussed.

The course will be divided up into five live online sessions, the date and times are as follows:

Monday, June 2 | 2.00pm – 5.30pm BST
Tuesday, June 3 | 2.00pm – 5.30pm BST
Wednesday, June 4 | 2.00pm – 5.30pm BST
Thursday, June 5 | 2.00pm – 5.30pm BST
Friday, June 6 | 2.00pm – 5.30pm BST

 

Course Outline

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Introduction: Overview of drug discovery process, target selection in the post-genomic era
Introduction to Medicinal Chemistry, definitions, QSAR studies, drug receptors, physico-chemical properties
Physico-chemical properties of drugs, and implications for Absorption
Lead generation approaches
Lead generation using computational techniques: molecular recognition, structure- and ligand-based virtual screening, success stories
Molecular diversity and combinatorial design
Pharmacokinetics and ADME, with examples
Introduction to Lead Optimisation, Case Studies
Overview of some of the reasons for project failure, of Safety, in particular to its relationship to chemical structure and of critical issues in Drug Development
Intellectual property issues related to drug discovery
What happens next? – a (very) brief overview of process development issues

Benefits of Attending

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  • An understanding of how biological disease targets are selected.
  • An insight into the terms, definitions and analysis methods used by medicinal chemists in the pharmaceutical industry.
  • An introductory knowledge of Pharmacokinetics and ADME (Absorption, Distribution, Metabolism and Excretion) and how physicochemical properties influence absorption.
  • An introduction to the use of computational chemistry including pharmacophore generation, virtual screening and library design.
  • An overview of safety assessment and how chemical structure relates to safety.
     

Who Should Attend

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  • Young chemists who have just started in industry as medicinal chemists.
  • Experienced medicinal chemists who wish to gain additional knowledge on how to obtain compounds with optimal drug-like properties and get up to date with the latest thinking.
  • Chemists from other areas of Research and Development who would like to gain an appreciation of the processes and drivers involved in drug discovery.
  • Students who are planning a career in industry and can obtain company sponsorship

What's Included

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The course fee includes:

  • Link to watch all five live sessions
  • Electronic version of the course manual*
  • Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.

Other Information

Sepcial Offers

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1st delegate fee = Full price
2nd delegate fee = 5% off
3rd delegate fee = 10% off
4 or more delegate fees = 15% off

For more information on offers, do give us a call on  +44 (0) 1892 956 222

Certificate of Attendance

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Upon completion of the course, participants can request a Certificate of Attendance.

Registration

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Medicinal Chemistry

02 June 2025 - 06 June 2025
Online Event