Kinetic Modelling: What’s in it for me and how to get started

Date: 23 March - 24 March 2021

Location: Online Event

Tutors: Dr Charles M Gordon, Dr Will Watson

This is a NEW Online Short Course – Reaction kinetic models can provide critical process understanding, and speed the development of robust and optimized Active Ingredient processes for scale-up.   This short course provides an introduction to key aspects of physical organic chemistry and how they can be applied in a kinetic modelling approach.  The course features case studies from the pharmaceutical industry and its chemical supply chain, hands-on exercises and includes an optional day of further hands-on training with Reaction Lab™ software, the leading kinetic modelling platform for chemists in the pharmaceutical industry.

This course will be set over two days with an optional demonstration session on Reaction Lab™

March 23, 1.30 – 5.00 (UK) |  Session 1

March 24, 1.30 – 5.00 (UK) |  Session 2

FREE Optional Session – Introduction on Reaction Lab™

March 25, 1.30 – 5.00 (UK) |  Session 3

This course is run in conjunction with   

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Course Outline

Days 1-2: Kinetic Modelling: What’s in it for me and how to get started

  • Theory of reaction kinetics, including an explanation of rate laws with an introduction to first- and second-order reactions, rate-limiting steps and how the Arrhenius relationship can be applied to model kinetics.
  • Application of kinetic models to homogeneous systems and the effects of pre-equilibria, pKa and competitive reactions.
  • Application of kinetic models to heterogeneous systems and the effects of kLA: dissolution of substrate, hydrogenation and biocatalysis.
  • Application of kinetic models to continuous systems and design of Plug Flow Reactors and Continuous Stirred Tank Reactors.
  • Workflows for experimental design and data collection, including internal standards, the importance of a mass balance, and sampling.

Day 3: Introduction to Reaction Lab™

  • Building a kinetic model from scratch
  • Simulation and fitting of experimental data to determine kinetic parameters
  • Optimization of process conditions
  • Generation of a simulated response surfaces to assess process robustness
  • Reaction Lab™ models of heterogeneous and catalytic systems

Who Should Attend

Process development chemists who want to improve their understanding of physical organic chemistry and reaction kinetics.

What's Included

 

  • A protected e-reader version of the slides
    (please note you will be able to print the electronic version and it will be accessible for a minimum of 1 year. However, if you wish to purchase a professionally printed colour version of the manual this will be an additional cost)
  • Course Certificate
  • A link to download Reaction Lab™ and license for those attending the optional Day 3.

Testimonials

Virtual Delegate 2020

I really enjoyed the virtual Short Course and it was very good incl. the thorough collection of examples etc.

Looking forward to the next ones!