Archived: Industrial Phase-Transfer Catalysis

A 2 day course presented by Dr Marc Halpern, PTC Organics, Inc., USA

Date: 02 October - 03 October 2018

Location: Hyatt House King of Prussia, Philadelphia

Tutors: Dr Marc Halpern

This Phase-Transfer Catalysis (PTC) course has an unmatched return on investment of your company’s training budget because it directly focuses on helping your company achieve low-cost, high-performance green chemistry processes. The results are almost immediate and apply to all stages of process R&D from route selection to process development to plant support. Your company benefits from improved R&D efficiency, higher process performance and increased profit. This PTC course is unique in that it is relevant to about 25% of all organic reactions and is therefore immediately applicable to current projects in all areas of the organic chemical industry!

This course split into two modules:

  1. Choose PTC Process Conditions Like an Expert
  2. PTC Applications: Critical Review of 200 Reactions

This highly rated industrial PTC course has been conducted 53 times since 1996 (formerly under the name “Practical Phase-Transfer Catalysis), of which 32 were conducted in-house at process R&D departments for pharmaceuticals, agrochemicals, flavors & fragrances, dyes & pigments and a variety of commodity, specialty and fine organic chemical manufacturers. Customers often report huge savings for existing processes, processes in development and greatly improved performance in route selection within weeks or months of conducting this course in-house or attending a public PTC course. Several companies have conducted this course in-house twice!

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Course Outline

Day 1: Choose PTC Process Conditions Like an Expert

Learn how to systematically and rapidly choose process conditions and practical workup for PTC processes to achieve the lowest cost highest performance green chemistry. Learn the comprehensive fundamentals and practical guidelines for choosing phase-transfer catalyst (structure-activity relationships, catalyst separation, catalyst stability), solvent, hydration, anions, leaving groups, agitation, highly specialized techniques and specific guidelines for evaluating new PTC applications in 3-5 experiments. Dr. Halpern invented the “Halpern pKa Guidelines for Evaluation and Optimization of New PTC Applications” and he also invented the q-value structure-activity parameter that characterizes the accessibility of the positive charge of quaternary onium salts that affects ion pairing.

Halpern pKa Guidelines

Day 1 is not only the most important day of the PTC course, it is the investment that will save your company weeks and months of development time AND result in much higher process performance and profit (higher yield, shorter reaction time, reducing excess reactants, better selectivity, effective workup, replacing expensive hazardous strong base, replacing hard-to-recover solvents, eliminating unit operations, etc.).


Day 2: PTC Applications: Critical Review of 200 Reactions in 30 Reaction Categories

While Day 1 teaches you how to choose PTC reaction conditions like an expert to achieve high performance, Day 2 is the perfect follow up that shows you the extremely broad scope of applications in which PTC excels that leverage the concepts learned in Day 1. In Day 2, the participants are guided through critique of 200 PTC patented and published applications in 30 reaction categories using the fundamentals and guidelines from Day 1 to understand or improve upon the impressive performance of these PTC reactions.Module 2 sample

The PTC reactions analyzed in Day 2 include C-Alkylation, Chiral Alkylation, O-Alkylation (Etherification), S-Alkylation, N-Alkylation, Ambident Alkylation, Michael Addition, Aldol Condensation, Wittig, Other Condensations, Dehydrohalogenation, Carbene Reactions, Hydrolysis, Esterification, Transesterification, Acylation, Phosphorylation, Tosylation, Carbamoylation, Other PTC Reactions with Water-Sensitive Compounds, Nucleophilic Substitutions with Cyanide , Azide, Fluoride, Other Nucleophilic Aliphatic & Aromatic Substitutions, Oxidation, Epoxidation, Reduction, Carbonylation, Transition Metal Co-Catalysis, Suzuki Coupling, Chlorination, PTC-Acid Reactions and PTC Radical Reactions.


Who Should Attend

Industrial process chemists, engineers and their managers will learn the benefits and breakthroughs of phase-transfer catalysis for process R&D and production support.

This course will enable your company to achieve increased profit, R&D efficiency and process performance.

What's Included

The course fee includes:

  • comprehensive course manual
  • coffee/tea refreshments breaks throughout each day
  • buffet lunch each day
  • course certificate


Corning SAS

As usual a 2 day course allows us to learn a lot in a specific topic in a quite short time frame. This one is an outstanding and stimulating lecture in the field of PTC, so a rather good time “investment”!