Grignard Chemistry Short Course
Event overview
Grignard Chemistry is a cornerstone of modern organic synthesis. This course is designed to provide you with a comprehensive understanding of Grignard reagents, including their preparation, stability and safety and their diverse applications in organic chemistry. Named after Victor Grignard, who received the Nobel Prize in Chemistry in 1912 for this groundbreaking discovery, Grignard reagents have become indispensable tools for chemists seeking to form carbon-carbon bonds, a critical step in building complex molecules both on lab and industrial scales. The integration of continuous processing and flow chemistry will also be discussed.
Throughout this course, we will explore the theoretical foundations of Grignard reactions, delve into the practical aspects of handling these highly reactive organomagnesium compounds, and examine their role in the synthesis of building blocks and advanced intermediates. By the end of this course, you will be equipped with the knowledge and skills to effectively utilize Grignard chemistry in both academic and industrial settings, paving the way for innovative solutions in synthetic organic chemistry.
The course will be in two sections will be held over two consecutive days as follow:
Monday, December 2nd | 2.00 – 5.00 pm (UK)
Tuesday, December 3rd | 2.00 – 5.00 pm (UK)
Course Outline
Session 1: Making Grignard reagents and safety aspects of making and handling Grignard reagents.
This presentation will cover the main ways for preparing organomagnesium compounds, and consider their relative reactivity and stability once prepared. In addition the safety issues associated with making organomagnesium compounds will be discussed. The presentation will use real life case studies to illustrate the various aspects of preparation, stability and safety.
- Introduction
- Making Grignard reagents on scale
- Safety issues
Session 2: Recent examples of using Grignard reagents, and making Grignard reagents in continuous flow mode.
This presentation will cover recent developments in the use of Grignard reagents such as Kumada and Negishi couplings along with the preparation and use of Grignard reagents in flow with particular emphasis on the scale up of flow processes for the preparation of Grignard reagents via industrial case studies.
- Recent examples of using Grignard reagents
- Making Grignard reagents in continuous flow mode.
This online course will be of interest to anyone involved in synthetic organic chemistry, since every chemist will run at least one Grignard reaction in their life.
When you register you will be sent links to join the online sessions.
What's Included?
The course fee includes:
- Link to watch the two sessions live
- Electronic version of the course manual (e-reader)*
- Course certificate
For this online course, there will be no recordings available and *the e reader is NOT printable or downloadable (due to copyright). If you would prefer a physical copy, you will have the opportunity of purchasing a professionally printed version during the booking process.
Who Should Attend?
Brochure
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