Chemical and Process Safety for Development Chemists
Event overview
Chemical process safety incidents can be very different in nature, going from bulging reagent drums waiting to burst, over limited spills in the lab due to sudden gas release, to catastrophic runaway reactions in the plant. They mostly have one thing in common: understanding the interplay between the chemistry involved and the physical consequences could have prevented them.
In this course, the basics of chemical process safety are explained, always starting from the underlying chemistry. A lot of emphasis will be put on heat and gas evolution, how they affect the inherent process safety and how they can be measured in the lab. Basic scale-up calculations for both gas and heat evolution will be explained using examples and exercises. Guidelines will be given to prevent possible issues with heat transfer at larger scale. The importance of stability data of chemicals, reaction mixtures and products will be explained, together with different tools to determine them experimentally. Background will be provided to understand and interpret the results of reaction calorimetry and thermal stability experiments. Safety aspects of upstream or downstream processes like storage and waste streams will be discussed. The safety benefits of flow chemistry will be explained, and the specific safety evaluation needed for such flow processes will be explored as well.
Course Outline
Introduction
- Large scale batch equipment
Retrieving safety information
- Where to find safety information
- Pitfalls of SDS data
Chemical choices
- Choice of solvent
- Choice of reagent : the usual susptects
Process safety at larger scale
- Runaway scenario
- Criticality classes
Heat evolution
- Rules of thumb
- Reaction calorimetry
- Heat transfer coefficients
- Safe scale-up of heat removal
- Safety at reflux
- Calculation of dosing times
Gas evolution
- Rules of thumb
- Measuring gas evolution in the lab
- Safe scale-up of reactions with gas evolution
Study of the decomposition reaction
- Screening methods
- Adiabatic calorimetry
- Autocatalysis
- Determination of TMRad,24h
- Kinetic modelling
Upstream and downstream
- Safety aspects of storage of unstable chemicals
- Safety incidents with waste streams
Flow chemistry
- Safer processing in flow
- Safety evaluation of flow processing
Requirements for safety studies
- Intended process vs upset conditions
- Interaction matrix
- Chemical compatibility
Who Should Attend
- Lab chemists working in process development
- Chemical engineers working in chemical production and tech transfer
- R&D managers in chemical development
What the delegates will gain
- Understand the effect of heat and gas evolution on large scale synthesis
- Understand how preliminary lab data can give insight in possible safety issues at scale
- Understand how chemical reactivity can influence upstream and downstream issues in storage and waste streams
- Understand how chemistry involved can influence operational issues like heat transfer, gas removal and reflux
- Understand which data is needed for safe scale-up of batch processes
What's included
The course fee includes:
- comprehensive course manual
- coffee/tea refreshments breaks throughout each day
- buffet lunch each day
- course dinner on the first evening
- course certificate
Other Information
Discounts
1st delegate = full price
2nd delegate = 5% off
3rd delegate = 10% off
4 or more delegates = 15% off
For more information call us on +44 1892 956 222
Registration
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Download Booking FormChemical and Process Safety for Development Chemists
It was good. Never visited a Scientific Update conference, but will get it on my priority list. Very good – like the set-up, flow and topics. Very interested in process development.
Organic Process Research & Development Conference Delegate 2023
Thank you for the excellent conference. I enjoyed the scientific content and the networking opportunities. I will definitely recommend this conference to my colleagues.
The Formulation and Drug Delivery Congress Delegate
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