Chemical and Process Safety for Development Chemists

Date: 31 January - 08 February 2022

Location: Online Platform

Tutors: Dr Wim Dermaut

This NEW On Line Course will take place over four afternoon session set in UK Time.

Monday 31st January 2022 | 2.00 – 5.00pm
Tuesday 1st February 2022 | 2.00 – 5.00pm
Monday 7th February 2022 | 2.00 – 5.00pm
Tuesday 8th February 2022 | 2.00 – 5.00pm

Introduction

Chemical process safety incidents can be very different in nature, going from bulging reagent drums waiting to burst, over limited spills in the lab due to sudden gas release, to catastrophic runaway reactions in the plant. They mostly have one thing in common: understanding the interplay between the chemistry involved and the physical consequences could have prevented them.

In this course, the basics of chemical process safety are explained, always starting from the underlying chemistry. A lot of emphasis will be put on heat and gas evolution, how they affect the inherent process safety and how they can be measured in the lab. Basic scale-up calculations for both gas and heat evolution will be explained using examples and exercises. Guidelines will be given to prevent possible issues with heat transfer at larger scale. The importance of stability data of chemicals, reaction mixtures and products will be explained, together with different tools to determine them experimentally. Background will be provided to understand and interpret the results of reaction calorimetry and thermal stability experiments. Safety aspects of upstream or downstream processes like storage and waste streams will be discussed. The safety benefits of flow chemistry will be explained, and the specific safety evaluation needed for such flow processes will be explored as well.

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Course Outline

Introduction

  • Large scale batch equipment

Retrieving safety information

  • Where to find safety information
  • Pitfalls of SDS data

Chemical choices

  • Choice of solvent
  • Choice of reagent : the usual susptects

Process safety at larger scale

  • Runaway scenario
  • Criticality classes

Heat evolution

  • Rules of thumb
  • Reaction calorimetry
  • Heat transfer coefficients
  • Safe scale-up of heat removal
  • Safety at reflux
  • Calculation of dosing times

Gas evolution

  • Rules of thumb
  • Measuring gas evolution in the lab
  • Safe scale-up of reactions with gas evolution

Study of the decomposition reaction

  • Screening methods
  • Adiabatic calorimetry
  • Autocatalysis
  • Determination of TMRad,24h
  • Kinetic modelling

Upstream and downstream

  • Safety aspects of storage of unstable chemicals
  • Safety incidents with waste streams

Flow chemistry

  • Safer processing in flow
  • Safety evaluation of flow processing

Requirements for safety studies

  • Intended process vs upset conditions
  • Interaction matrix
  • Chemical compatibility

Who Should Attend

  • Lab chemists working in process development
  • Chemical engineers working in chemical production and tech transfer
  • R&D managers in chemical development

 

What the delegates will gain

  • Understand the effect of heat and gas evolution on large scale synthesis
  • Understand how preliminary lab data can give insight in possible safety issues at scale
  • Understand how chemical reactivity can influence upstream and downstream issues in storage and waste streams
  • Understand how chemistry involved can influence operational issues like heat transfer, gas removal and reflux
  • Understand which data is needed for safe scale-up of batch processes

What's included

The course fee includes:

  • Link to watch all four live sessions
  • Electronic version of the course manual*
  • Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.

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Chemical and Process Safety for Development Chemists

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Chemical and Process Safety for Development Chemists

This course is available as an In-House event upon request. Please provide your details and we will get back to you with further information.

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