Chemical and Process Safety for Development Chemists

Date: 29 May - 30 May 2024

Location: Amsterdam, The Netherlands

Tutors: Dr Wim Dermaut

Chemical process safety incidents can be very different in nature, going from bulging reagent drums waiting to burst, over limited spills in the lab due to sudden gas release, to catastrophic runaway reactions in the plant. They mostly have one thing in common: understanding the interplay between the chemistry involved and the physical consequences could have prevented them.

In this course, the basics of chemical process safety are explained, always starting from the underlying chemistry. A lot of emphasis will be put on heat and gas evolution, how they affect the inherent process safety and how they can be measured in the lab. Basic scale-up calculations for both gas and heat evolution will be explained using examples and exercises. Guidelines will be given to prevent possible issues with heat transfer at larger scale. The importance of stability data of chemicals, reaction mixtures and products will be explained, together with different tools to determine them experimentally. Background will be provided to understand and interpret the results of reaction calorimetry and thermal stability experiments. Safety aspects of upstream or downstream processes like storage and waste streams will be discussed. The safety benefits of flow chemistry will be explained, and the specific safety evaluation needed for such flow processes will be explored as well.

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Course Outline

Introduction

  • Large scale batch equipment

Retrieving safety information

  • Where to find safety information
  • Pitfalls of SDS data

Chemical choices

  • Choice of solvent
  • Choice of reagent : the usual susptects

Process safety at larger scale

  • Runaway scenario
  • Criticality classes

Heat evolution

  • Rules of thumb
  • Reaction calorimetry
  • Heat transfer coefficients
  • Safe scale-up of heat removal
  • Safety at reflux
  • Calculation of dosing times

Gas evolution

  • Rules of thumb
  • Measuring gas evolution in the lab
  • Safe scale-up of reactions with gas evolution

Study of the decomposition reaction

  • Screening methods
  • Adiabatic calorimetry
  • Autocatalysis
  • Determination of TMRad,24h
  • Kinetic modelling

Upstream and downstream

  • Safety aspects of storage of unstable chemicals
  • Safety incidents with waste streams

Flow chemistry

  • Safer processing in flow
  • Safety evaluation of flow processing

Requirements for safety studies

  • Intended process vs upset conditions
  • Interaction matrix
  • Chemical compatibility

Who Should Attend

  • Lab chemists working in process development
  • Chemical engineers working in chemical production and tech transfer
  • R&D managers in chemical development

 

What the delegates will gain

  • Understand the effect of heat and gas evolution on large scale synthesis
  • Understand how preliminary lab data can give insight in possible safety issues at scale
  • Understand how chemical reactivity can influence upstream and downstream issues in storage and waste streams
  • Understand how chemistry involved can influence operational issues like heat transfer, gas removal and reflux
  • Understand which data is needed for safe scale-up of batch processes

What's included

The course fee includes:

  • comprehensive course manual
  • coffee/tea refreshments breaks throughout each day
  • buffet lunch each day
  • course dinner on the first evening
  • course certificate

Testimonials

CHEMICAL AND PROCESS SAFETY FOR DEVELOPMENT CHEMISTS Online 2022

Thank you for an interesting course providing me useful knowledge I can take back to my work so I can help keep our processes safe by design and how we run them.

CHEMICAL AND PROCESS SAFETY FOR DEVELOPMENT CHEMISTS Online 2022

Very useful course for development and production chemists. From toxicity to reactivity and thermal stability, safety is crucial in our work. When you attend to this course you want to know more about the subject

CHEMICAL AND PROCESS SAFETY FOR DEVELOPMENT CHEMISTS Online 2022

I recommend the course because the speaker is highly competent and available for further informations and opportunities for improvement

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