Carbon-Carbon Bond Formation in Organic Synthesis- Methodology, Troubleshooting and Industrial Application
Event overview
| New Course |
This new online course provides a comprehensive exploration of carbon–carbon (C–C) bond-forming methodologies, focusing on both traditional and cutting-edge techniques employed in modern organic synthesis. Designed for advanced students, discovery and development chemists and professionals in the chemical sciences, it integrates mechanistic understanding with practical insights relevant to both laboratory-scale and industrial applications.
Through this course, participants will gain not only a deep theoretical understanding but also the practical tools needed to design, troubleshoot, and optimize C–C bond-forming reactions in a variety of synthetic contexts. The course uses case-studies and modern interactive tools to re-enforce understanding and promote collaboration.
This online course will cover 5 sections, over a two afternoon sessions: 2.00 – 5.30pm (UK, BST Time)
Wednesday 17 September | 2.00pm – 5.30pm BST
Thursday 18 September | 2.00pm – 5.30pm BST
Course Outline
The first section covers classical stoichiometric organometallic reagents—lithium, magnesium (Grignard), and zinc—emphasizing their formation, utility, and recent advances, along with crucial safety considerations when handling highly reactive species.
The second section delves into palladium-catalysed C–C coupling reactions, a cornerstone of modern synthetic chemistry. A wide range of coupling types will be discussed, including Suzuki-Miyaura, Heck, Sonogashira, Negishi, Stillie, miscellaneous biaryl couplings, ketone α-arylation, carbonylation, cyanation, decarboxylative coupling, ring-closing metathesis and more, alongside the preparation of alkyl and aryl boron-based substrates, troubleshooting problematic reactions, and strategies for metal removal in compliance with regulatory guidelines.
Section 3 introduces a systematic approach to reaction selection and optimization, including the use of decision trees, Design of Experiment (DoE), and visualization tools. Relevant case studies from industrial settings will highlight practical challenges and solutions
The penultimate section explores emerging methodologies such as photoredox catalysis, C–H activation, and electrochemical approaches, focusing on screening techniques and their application in C–C bond formation.
The final section addresses the growing interest in sustainability and non-precious metal catalysis, particularly nickel and copper -mediated transformations, with an emphasis on scalability, green chemistry and recent innovations.
Who Should Attend
Synthetic organic chemists in industry and academia
Process development chemists and those involved in route design/optimisation
Anyone wishing to learn more about C-C cross-coupling chemistry
Benefits of Attending
People attending the course will:
- Gain practical insights for designing, troubleshooting, and optimizing C–C bond-forming reactions across diverse synthetic applications.
- Learn to select optimal reagents for specific substrates and identify critical reaction parameters.
- Broaden expertise in both established and emerging C–C coupling methodologies, including considerations for scale-up, safety, and new technologies.
Other Information
What's Included
The course fee includes:
- Link to watch all live sessions
- Electronic version of the course manual*
- Course certificate
For this online course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright). If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.
Course Certificate
Upon completion of the course, participants can request a Certificate of Attendance.
Brochure
View Summary
Become a speaker at one of our events
Share your expertise with a global audience of industry professionals. Scientific Update is continually seeking thought leaders and industry innovators to speak at our renowned conferences and training courses.
