Archived: Biocatalysis as a Tool for the Synthetic Chemist

• Introduction to Biocatalysis

  Literature sources for biocatalysis (books and review articles)
  Myths about biocatalysis / pros and cons of biocatalysis
  Enzyme / protein basics, basic microbiology
  Sources of biocatalysts
  Equipment requirements
  Enzyme types

  Hydrolytic Enzymes (Lipases, esterases, amidases, proteases)

  Mechanism of hydrolysis by enzymes
  Kinetic resolution
  Use of organic solvents
  Dynamic kinetic resolution (DKR)
  Deracemisation
  Ester, amide, nitrile and epoxide hydrolysis
  concentration

  Oxidations

  Alcohol oxidation
  Amine oxidation, deracemisation of amines and amino acids
  Bio-oxygenation, bio-hydroxylation
  Demethylation
  Epoxidation
  Bayer-Villiger oxidation
  Sulphoxidation

  Reduction

  Ketone reduction, Prelog rules
  Co-factors
  Deracemisation of secondary alcohols
  Enantioselective reduction / DKR
  Keto-ester reduction
  C=C reduction

• C-C and C-X bond formation

  Aldol reactions
  Transketolases
  Cross benzoin reactions
  Hydroxy-nitrile lyases
  Michael reactions
  Transamination
  Fumarase and aspartase

  Scale Up of Biotransformations

  Reactors
  Case studies

  New Developments including Directed Evolution

  Polymerase Chain Reaction
  Mutagenesis
  Directed Evolution
  Product isolation

  Pros and Cons of Biocatalysis

  Summary
  Q&A, discussion

   

   

 

• Any Organic Chemist involved in synthesis, particularly those involved in designing novel, green synthetic routes.
• Chemists who want to learn how biocatalysis can help them.
• Those involved in the scale-up of biocatalytic reactions.

 

The course fee includes:

• Link to watch all five live sessions
• Electronic version of the course manual*
• Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.

Biocatalysis as a Tool for the Synthetic Chemist - Online Delegate 2022

Interestisting and helpful course, perfect for those starting in the biocatalysis field.

Biocatalysis Online Delegate 2021

Well organized and knowledgeable presenters. Course was full of very relevant information on approaches to biocatalysis from feasibility through industrialization with a nice spectrum of case studies on biocatalysis in fine chemicals and pharma. Appreciated the points made on opportunities with biocatalysis and other points beyond the chemistry that need to be considered (economics, quality, regulatory) when deciding on a biocatalytic vs. chemical route.

Online Givaudan Delegate

A broad type of enzymatic reaction was described. Tips and hints are very useful.

Online Sigma Aldrich Production GmbH Delegate