Biocatalysis as a Tool for the Synthetic Chemist

Introduction to Biocatalysis

Literature sources for biocatalysis (books and review articles)
Myths about biocatalysis / pros and cons of biocatalysis
Enzyme / protein basics, basic microbiology
Sources of biocatalysts
Equipment requirements
Enzyme types

Hydrolytic Enzymes (Lipases, esterases, amidases, proteases)

Mechanism of hydrolysis by enzymes
Kinetic resolution
Use of organic solvents
Dynamic kinetic resolution (DKR)
Deracemisation
Ester, amide, nitrile and epoxide hydrolysis
concentration

Oxidations

Alcohol oxidation
Amine oxidation, deracemisation of amines and amino acids
Bio-oxygenation, bio-hydroxylation
Demethylation
Epoxidation
Bayer-Villiger oxidation
Sulphoxidation

Reduction

Ketone reduction, Prelog rules
Co-factors
Deracemisation of secondary alcohols
Enantioselective reduction / DKR
Keto-ester reduction
C=C reduction

C-C and C-X bond formation

Aldol reactions
Transketolases
Cross benzoin reactions
Hydroxy-nitrile lyases
Michael reactions
Transamination
Fumarase and aspartase

Scale Up of Biotransformations

Reactors
Case studies

New Developments including Directed Evolution

Polymerase Chain Reaction
Mutagenesis
Directed Evolution
Product isolation

Pros and Cons of Biocatalysis

Summary
Q&A, discussion

• Any Organic Chemist involved in synthesis, particularly those involved in designing novel, green synthetic routes.
• Chemists who want to learn how biocatalysis can help them.
• Those involved in the scale-up of biocatalytic reactions.

 

The course fee includes:

• Link to watch all five live sessions
• Electronic version of the course manual*
• Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.

Biocatalysis as a Tool for the Synthetic Chemist - Online Delegate 2022

Interestisting and helpful course, perfect for those starting in the biocatalysis field.

Biocatalysis Online Delegate 2021

Well organized and knowledgeable presenters. Course was full of very relevant information on approaches to biocatalysis from feasibility through industrialization with a nice spectrum of case studies on biocatalysis in fine chemicals and pharma. Appreciated the points made on opportunities with biocatalysis and other points beyond the chemistry that need to be considered (economics, quality, regulatory) when deciding on a biocatalytic vs. chemical route.

Online Givaudan Delegate

A broad type of enzymatic reaction was described. Tips and hints are very useful.

Online Sigma Aldrich Production GmbH Delegate