Biocatalysis as a Tool for the Synthetic Chemist

Date: 27 March - 30 March 2023

Location: Online Platform

Tutors: Dr Andrew Wells

We are delighted to offer this course now ONLINE, the two day course has now been divided up into four sessions, which will be presented via a virtual on line system.  Dates and timings are as follows in UK time:

Monday March 27th | 2.00pm – 5.00pm UK
Tuesday March 28th | 2.00pm – 5.00pm UK
Wednesday March 29th
| 2.00pm – 5.00pm UK
Thursday March 30th | 2.00pm – 5.00pm UK

The aim of the course is to give organic chemists an understanding and an overview of the subject of biotransformations.

Attendees will learn about the main classes of enzymes and the transformations these enzymes carry out.

Each transformation type will be illustrated with examples and case studies and the course will also include problem sessions where attendees will work on real examples applying biotransformations to organic synthesis.

Recent developments in the field will be covered as well as an overview of the sort of equipment and resources required.

Please do view the brochure for more information (please note this is based on the live 2 day course, but the content is the same)

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Course Outline

  • Introduction to Biocatalysis

    Literature sources for biocatalysis (books and review articles)
    Myths about biocatalysis / pros and cons of biocatalysis
    Enzyme / protein basics, basic microbiology
    Sources of biocatalysts
    Equipment requirements
    Enzyme types

    Hydrolytic Enzymes (Lipases, esterases, amidases, proteases)

    Mechanism of hydrolysis by enzymes
    Kinetic resolution
    Use of organic solvents
    Dynamic kinetic resolution (DKR)
    Deracemisation
    Ester, amide, nitrile and epoxide hydrolysis
    concentration

    Oxidations

    Alcohol oxidation
    Amine oxidation, deracemisation of amines and amino acids
    Bio-oxygenation, bio-hydroxylation
    Demethylation
    Epoxidation
    Bayer-Villiger oxidation
    Sulphoxidation

    Reduction

    Ketone reduction, Prelog rules
    Co-factors
    Deracemisation of secondary alcohols
    Enantioselective reduction / DKR
    Keto-ester reduction
    C=C reduction

  • C-C and C-X bond formation

    Aldol reactions
    Transketolases
    Cross benzoin reactions
    Hydroxy-nitrile lyases
    Michael reactions
    Transamination
    Fumarase and aspartase

    Scale Up of Biotransformations

    Reactors
    Case studies

    New Developments including Directed Evolution

    Polymerase Chain Reaction
    Mutagenesis
    Directed Evolution
    Product isolation

    Pros and Cons of Biocatalysis

    Summary
    Q&A, discussion

     

     

 

Who Should Attend

  • Any Organic Chemist involved in synthesis, particularly those involved in designing novel, green synthetic routes.
  • Chemists who want to learn how biocatalysis can help them.
  • Those involved in the scale-up of biocatalytic reactions.

 

What's Included

The course fee includes:

  • Link to watch all five live sessions
  • Electronic version of the course manual*
  • Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright).  If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.

Testimonials

Biocatalysis as a Tool for the Synthetic Chemist - Online Delegate 2022

Interestisting and helpful course, perfect for those starting in the biocatalysis field.

Biocatalysis Online Delegate 2021

Well organized and knowledgeable presenters. Course was full of very relevant information on approaches to biocatalysis from feasibility through industrialization with a nice spectrum of case studies on biocatalysis in fine chemicals and pharma. Appreciated the points made on opportunities with biocatalysis and other points beyond the chemistry that need to be considered (economics, quality, regulatory) when deciding on a biocatalytic vs. chemical route.

Online Givaudan Delegate

A broad type of enzymatic reaction was described. Tips and hints are very useful.

Online Sigma Aldrich Production GmbH Delegate

Great overview of the world of enzyme catalyzed reactions.

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Biocatalysis as a Tool for the Synthetic Chemist

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Biocatalysis as a Tool for the Synthetic Chemist

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