Biocatalysis as a Tool for the Synthetic Chemist

18 March 2024 - 21 March 2024

Online Event

Event overview

Course tutors: Dr Andrew Wells

We are delighted to offer this course now ONLINE, the two day course has now been divided up into four sessions, which will be presented via a virtual on line system. Dates and timings are as follows in UK time:

Monday March 18th | 2.00pm – 5.00pm UK
Tuesday March 19th | 2.00pm – 5.00pm UK
Wednesday March 20th | 2.00pm – 5.00pm UK
Thursday March 21st | 2.00pm – 5.00pm UK

The aim of the course is to give organic chemists an understanding and an overview of the subject of biotransformations.

Attendees will learn about the main classes of enzymes and the transformations these enzymes carry out.

Each transformation type will be illustrated with examples and case studies and the course will also include problem sessions where attendees will work on real examples applying biotransformations to organic synthesis.

Recent developments in the field will be covered as well as an overview of the sort of equipment and resources required.

Please do view the brochure for more information (please note this is based on the live 2 day course, but the content is the same)

Course Outline

Introduction to Biocatalysis

Literature sources for biocatalysis (books and review articles)
Myths about biocatalysis / pros and cons of biocatalysis
Enzyme / protein basics, basic microbiology
Sources of biocatalysts
Equipment requirements
Enzyme types

Hydrolytic Enzymes (Lipases, esterases, amidases, proteases)

Mechanism of hydrolysis by enzymes
Kinetic resolution
Use of organic solvents
Dynamic kinetic resolution (DKR)
Deracemisation
Ester, amide, nitrile and epoxide hydrolysis
concentration

Oxidations

Alcohol oxidation
Amine oxidation, deracemisation of amines and amino acids
Bio-oxygenation, bio-hydroxylation
Demethylation
Epoxidation
Bayer-Villiger oxidation
Sulphoxidation

Reduction

Ketone reduction, Prelog rules
Co-factors
Deracemisation of secondary alcohols
Enantioselective reduction / DKR
Keto-ester reduction
C=C reduction

C-C and C-X bond formation

Aldol reactions
Transketolases
Cross benzoin reactions
Hydroxy-nitrile lyases
Michael reactions
Transamination
Fumarase and aspartase

Scale Up of Biotransformations

Reactors
Case studies

New Developments including Directed Evolution

Polymerase Chain Reaction
Mutagenesis
Directed Evolution
Product isolation

Pros and Cons of Biocatalysis

Summary
Q&A, discussion

Who Should Attend

Any Organic Chemist involved in synthesis, particularly those involved in designing novel, green synthetic routes.
Chemists who want to learn how biocatalysis can help them.
Those involved in the scale-up of biocatalytic reactions.

What's Included

The course fee includes:

Link to watch all five live sessions
Electronic version of the course manual*
Course certificate

For this on line course, there will be no recordings available and *the e reader manual is NOT printable or downloadable (due to copyright). If you prefer a hard copy of the manual you will have the opportunity of purchasing a professionally printed hard copy during the booking process.

Other Information

Discounts

1st delegate = full price
2nd delegate = 5% off
3rd delegate = 10% off
4 or more delegates = 15% off
For more information on discounts do give us a call on 44 1435 873 062

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Biocatalysis as a Tool for the Synthetic Chemist

Event overview

Course Outline

Introduction to Biocatalysis

Hydrolytic Enzymes (Lipases, esterases, amidases, proteases)

Oxidations

Reduction

C-C and C-X bond formation

Scale Up of Biotransformations

New Developments including Directed Evolution

Pros and Cons of Biocatalysis

Who Should Attend

What's Included

Other Information

Discounts

Biocatalysis as a Tool for the Synthetic Chemist

Fee info

Venue info

Become a speaker at one of our events