Applied Mixing Technology for Process Development: Scaling Down to Scale Up

Date: 17 March - 18 March 2022

Location: New Orleans, USA

Tutors: Aaron Sarafinas

Course Introduction

This NEW COURSE will be held over two days.  Use of the proper mixing technology is often essential for successful process results.  This course considers how we can choose appropriate mixing conditions for laboratory, pilot, and commercial scale units to ensure technical success.  The course begins by rooting us in some essential basics of mixing technology.  With those fundamentals, we then progress through different mixing applications in increasing levels of complexity:  single-phase (blending and heat transfer), multiple phase (solid-liquid, immiscible liquid, gas-liquid, and 3-phase), and mixing in competitive rate processes (reactions and crystallizations).  Throughout, we look at scale-up and scale-down by using examples from industrial processes which have a variety of mixing requirements.  We will discuss how to design and execute practical experiments at the small scale which can identify mixing sensitivities in a process that could be an issue on scale-up.  Though primarily focusing on operations in stirred tanks, we will also discuss mixing applications in flow systems like static mixers.

 

 

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Course Outline

  • Why learn about mixing and what is “mixing” anyway?
  • An introduction to some example industrial processes with multiple mixing requirements
  • Foundations of mixing technology:  power, flow, and “shear” (with some discussion of rheology)
  • An introduction to mixing applications, revisiting the example processes
  • Single-phase mixing applications and how they scale
    • Miscible liquid blending (macromixing)
    • Heat transfer
  • Multiple-phase mixing applications and how they scale
    • Solid-liquid mixing
    • Liquid-liquid dispersion
    • Gas-liquid dispersion
    • Three-phase mixing
  • Competitive rate processes (micromixing and mesomixing)
    • Mixing-sensitive reactions
    • Crystallizations and precipitations
  • An efficient experimental method for screening mixing sensitivities:  the Bourne Protocol
  • Balancing different mixing requirements during scale-up and scale-down:  scaling competitive rate processes and optimization

Who Should Attend

Scientists and engineers in the chemical and pharmaceutical industries who are involved in process development, scale-up/scale-down, troubleshooting, and process optimization.

Take-home Messages

  • Mixing moderates some rate processes that can be critical for successful process results.
  • Power, flow, and “shear” are the foundation upon which we can evaluate mixing applications.
  • Predicable mixing performance can be estimated for single phase and multiple phase systems, along with the boundaries of “not enough mixing” and “too much mixing”.
  • You cannot keep all mixing parameters the same when you scale up.

What's included

The course fee includes:

  • The course fee includes:
    • comprehensive course manual
    • coffee/tea refreshments breaks throughout each day
    • buffet lunch each day
    • course dinner on the first evening
    • course certificate

You are responsible for booking and paying for your own accommodation details on the venue will be sent upon confirmation.

Testimonials

2021 Online Delegate

The mixing technology course was very insightfull. A lot of eye-openers and really applicable knowledge by an excellent tutor

Online delegate 2021

Many complex concepts are so easily explained that everyone can understand. It has content from basics to advance level and touches upon all key areas of mixing. I highly recommend this course for chemists and process engineers.

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Applied Mixing Technology for Process Development: Scaling Down to Scale Up

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Applied Mixing Technology for Process Development: Scaling Down to Scale Up

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