Applied Mixing Technology for Process Development: Scaling Down to Scale Up

Understand the many ways mixing can affect your chemical process and design appropriate studies to avoid unpleasant surprises on scale-up

4 Sessions
Online - Live & Interactive
1 Tutor
AS

Aaron Sarafinas

Course tutor

It was nice experience to attend this training and definitely it will enhance skill to scale-up w.r.t. mixing and my company will also get benefited.
Applied Mixing - April 2024, Online attendee Previous attendee, Applied Mixing - April 2024, Online attendee
The course content was comprehensive and engaging. Aaron's passion and expertise for the topic was evident through the session, and he showed dedication to our learning by giving personalized feedback to our questions. I am confident I have gained skills and knowledge to apply what I have learned to my own work.
Applied Mixing - April 2024, Online attendee Previous attendee, Applied Mixing - April 2024, Online attendee
The course is very comprehensive and can be applied directly to the daily work. Very appreciated the scientific references provide throughout the training.
Applied Mixing - April 2024, Online attendee Previous attendee, Applied Mixing - April 2024, Online attendee
A very helpful deep-dive to understand mixing associated phenomena and how to address them in our processes. Thank you very much!
Applied Mixing Previous attendee, September 2023

About This Course

Use of the proper mixing technology is often essential for successful process results. This online course considers how we can choose appropriate mixing conditions for laboratory, pilot, and commercial scale units to ensure technical success. The course begins by rooting us in some essential basics of mixing technology. With those fundamentals, we then progress through different mixing applications in increasing levels of complexity: single-phase (blending and heat transfer), multiple phase (solid-liquid, immiscible liquid, gas-liquid, and 3-phase), and mixing in competitive rate processes (reactions and crystallizations). Throughout, we look at scale-up and scale-down by using examples from industrial processes which have a variety of mixing requirements. We will discuss how to design and execute practical experiments at the small scale which can identify mixing sensitivities in a process that could be an issue on scale-up. Though primarily focusing on operations in stirred tanks, we will also discuss mixing applications in flow systems like static mixers.


Who Should Attend

  • Scientists and engineers in the chemical and pharmaceutical industries who are involved in process development, scale-up/scale-down, troubleshooting, and process optimization

Format & Delivery

Format Online
Duration 4 Sessions
In-House Available for in-house delivery
Tutor Aaron Sarafinas

Course Outline

  • Module 1

    Why learn about mixing and what is “mixing” anyway? - An introduction to some example industrial processes with multiple mixing requirements - Begin Foundations of mixing technology: power, flow, and “shear” (with some discussion of rheology)

  • Module 2

    Finish Foundations of mixing technology: power, flow, and “shear” (with some discussion of rheology) - An introduction to mixing applications, revisiting the example processes - Single-phase mixing applications and how they scale - Miscible liquid blending (macromixing) - Heat transfer

  • Module 3

    Multiple-phase mixing applications and how they scale - Solid-liquid mixing - Liquid-liquid dispersion - Gas-liquid dispersion - Three-phase mixing

  • Module 4

    Competitive rate processes (micromixing and mesomixing) - Mixing-sensitive reactions - Crystallizations and precipitations - An efficient experimental method for screening mixing sensitivities: the Bourne Protocol - Balancing different mixing requirements during scale-up and scale-down: scaling competitive rate processes and optimization

Learning Outcomes

By the end of this course you will be able to:

  • Mixing moderates some rate processes that can be critical for successful process results
  • Power, flow, and 'shear' are the foundation upon which we can evaluate mixing applications
  • Predicable mixing performance can be estimated for single phase and multiple phase systems, along with the boundaries of u201cnot enough mixingu201d and 'too much mixing'
  • You cannot keep all mixing parameters the same when you scale up

Your Tutors

Aaron Sarafinas

Sarafinas Process & Mixing Consulting LLC

Aaron Sarafinas is a recognized expert in process development and mixing technology in the chemical and pharmaceutical industries.  He left Dow/Rohm and Haas after almost 36 years of being the bridge between the R&D lab and production units for many different business areas on a wide variety of processes.  He formed Sarafinas Process & Mixing Consulting LLC in June 2018 so clients can achieve faster process development, scaling, and troubleshooting while leveraging advantaged mixing technology.

  • Experienced Problem Solving
    35+ years of solving tough chemical processing problems at all scales
    Many projects saving time and money for clients since June 2018
  • Faster Process Development and Troubleshooting
    Quicker and more reliable scale-up and scale-down
    Efficient techniques to build process understanding
  • Does Mixing Matter?
    Efficiently determine how mixing technology affects process results
    Design the process with the commercial scale in mind
  • Simpler and Improved Processes
    Generate and select superior process technology options
    Optimize processes through functional and mechanistic systems thinking
  • Managing and Growing Technical Capabilities
    Create technology connections within and across organizations using Communities of Practice
    Raise working level knowledge of technical communities
  • Technical Training
    Develops and delivers effective process technology training (on-site and virtualUpcoming: Scientific Update course on “Applied Mixing Technology for Process Development:  Scaling Down to Scale Up”
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What Attendees Say

It was nice experience to attend this training and definitely it will enhance skill to scale-up w.r.t. mixing and my company will also get benefited.
Applied Mixing - April 2024, Online attendee Previous attendee, Applied Mixing - April 2024, Online attendee
The course content was comprehensive and engaging. Aaron's passion and expertise for the topic was evident through the session, and he showed dedication to our learning by giving personalized feedback to our questions. I am confident I have gained skills and knowledge to apply what I have learned to my own work.
Applied Mixing - April 2024, Online attendee Previous attendee, Applied Mixing - April 2024, Online attendee
The course is very comprehensive and can be applied directly to the daily work. Very appreciated the scientific references provide throughout the training.
Applied Mixing - April 2024, Online attendee Previous attendee, Applied Mixing - April 2024, Online attendee
A very helpful deep-dive to understand mixing associated phenomena and how to address them in our processes. Thank you very much!
Applied Mixing Previous attendee, September 2023
Interesting course presented with passion and involvement of the participants. Great expertise and knowledge made available to others
Applied Mixing Previous attendee, September 2023
The mixing technology course was very insightfull. A lot of eye-openers and really applicable knowledge by an excellent tutor
2021 Online Delegate Previous attendee, Applied Mixing
Many complex concepts are so easily explained that everyone can understand. It has content from basics to advance level and touches upon all key areas of mixing. I highly recommend this course for chemists and process engineers.
Online delegate 2021 Previous attendee, Applied Mixing

Course Dates

19-22 Oct 2026 Online - 4 Sessions - Booking open
  • PDT: 6.00am-09.00am
  • CDT: 8.00am-11.00am
  • EDT: 9.00am-12.00pm
  • BST: 2.00pm-5.00pm
  • CEST: 3.00pm-6.00pm
View & book →
19-22 Apr 2027 Online - 4 Sessions - Booking open
  • PDT: 6.00am-09.00am
  • CDT: 8.00am-11.00am
  • EDT: 9.00am-12.00pm
  • BST: 2.00pm-5.00pm
  • CEST: 3.00pm-6.00pm
View & book →
Have a group of 8 or more interested?

We can deliver this course as an in-house training solution, tailored to your team's needs. Groups of 8 or more attendees can be trained by our team of expert trainers, either at your facility or online.

Make an enquiry

Limited places · early booking recommended