If you are working in industry and are responsible for safety, how do you safely scale up a given chemical reaction? How do you tackle issues like heat transfer, gas release, exposure control, waste stream issues and more? The core of any process safety study is a correct description of both heat and gas release
Tag: Process Safety
I was recently standing with several colleagues on the mezzanine level of a small batch manufacturing plant watching an operator charge LiOH-H2O into a reactor manway. Without warning we were all suddenly hit with a punch to the throat from inhalation of invisible caustic dust that had aerosolized during the charging, and we were forced
When it comes to thermal hazard assessment, differential scanning calorimetry (DSC) takes a special place in the landscape of possible testing methods. Both for rapid screening of a wide variety of samples, and for the gathering of the necessary high-quality data for a detailed kinetic study of decomposition reactions, DSC is usually the instrument of
It’s not often that drug molecules find themselves on the reagent shelf alongside materials that may have been used to assemble them. The prince and the pauper so to speak. In 2019 Paul Hergenrother from the University of Illinois published a paper in Angewandte Chemie claiming a diazomethane surrogate that was a commercially available, weighable, solid:
