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Chemical Development and Scale Up

We spoke to chemists at different stages of their careers about their experiences of attending our ‘Chemical Development and Scale Up in the Fine Chemical and Pharmaceutical Industries’ training course. Ben Littler  Ben told us that he had taken the ‘Chem Dev’ course twice as an early career process chemist!  Both courses were held as

These Are Tri(azol)ing Times…. Great Chemistry- But Do Not Attempt on a Damp Day

Five-membered heterocyclic arenes account for a large portion of the heterocycles found in pharmaceuticals and bioactive molecules.1 Synthesis of heteroaryl halides and elaboration via metal catalysed cross coupling reactions- particularly with aliphatic amines- is, however, known to be challenging. These small heterocycles-particularly electron-rich systems- frequently coordinate to palladium, promoting catalyst deactivation via displacement of the supporting

One training course – Three different perspectives  

We spoke to chemists at different stages of their careers about their experiences of attending our ‘Chemical Development and Scale Up in the Fine Chemical and Pharmaceutical Industries’ training course. Ben Littler  Ben told us that he had taken the ‘Chem Dev’ course twice as an early career process chemist!  Both courses were held as

Young Chemist Award 2022 – Deadline to enter is 23 September

Our ‘Young Chemist Award’ – This competition helps young PhD chemists reach out to a wider industrial audience and gain recognition for their work. It can also help boost confidence as each finalist gets to present their work in a short presentation. Being selected as a finalist and getting the opportunity to present is in

Dr Jen Crawford at GSK is presenting at our ‘Organic Process R&D Conference’ in New Orleans 22-24 June

We are very pleased to introduce Dr Jen Crawford from GSK.  Jen will be talking about ‘Implementing Statistical Modelling Tools into Early Phase Process Development Workflows’ at our ‘Organic Process Research and Development Conference’ in New Orleans on 22-24 June. This presentation will describe high throughput experiments (HTE) which provide an opportunity to traverse large

Scientific Update speak to Dr Dustin Bringley, Gilead ahead of his presentation at ‘Organic Process Research & Development’ Conference in New Orleans on 22-24 June 2022

The count down has begun and we only have one month to go now until we come to New Orleans for our ‘47th Organic Process R&D Conference’ on 22-24 June. We are so excited about holding this face to face event in such a vibrant brilliant location!  The 3 day meeting will include 16 presentations

Rhodium takes Frigid Phenol to New Heights

Phenols and anilines are two of the most important building blocks in industrial chemical manufacturing. Any process capable of converting one into the other is going to generate a lot of interest, and a paper by Shi and co-workers does just that.1 Direct conversion of an aniline to a phenol is a relatively straightforward transformation

Metal Hydride? NO Protection, NO Problem and NO-Where to Hide

Process chemists at Genentech recently published their work on development of a kilo-scale synthesis of JAK-1 inhibitor- GDC-4379 (Figure 1).1The central heterocyclic core of the molecule consists of a 4-aminopyrazole moiety (elaborated as the pyrazolopyrimidene amide- presumably the inhibitor hinge binding fragment in the kinase active site) with an additional aryl substituent at C-3 and

Scientific Update – changing with the times during covid-19

As businesses around the world have had to postpone and cancel live meetings, conferences and training courses in response to COVID-19 disease, workplace and group training has become one of the earliest and hardest-hit business activities. We have found that 100% of companies we work with across the globe, have had to postpone or cancel their

Interview with Dr David Barnes from Abbvie who is speaking at our Organic Process R&D Conference in Clearwater, Florida 9-11 March.

Dr John Studley (JS) from Scientific Update spoke to Dr David Barnes (DB) from Abbvie in the US  ahead of our ‘Organic Process Research and Development’ Conference which is taking place in Clearwater, Florida on 9-11 March. We are looking forward to your presentation ‘Discovery of Novel Catalytic Technologies in the Development of Complex Clinical

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